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Risk of Polycystic Ovary Syndrome in Women Exposed to Fine Air Pollutants and Acidic Gases: A Nationwide Cohort Analysis

Author

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  • Shih-Yi Lin

    (Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung 40447, Taiwan
    Division of Nephrology and Kidney Institute, China Medical University Hospital, Taichung 40402, Taiwan)

  • Yu-Cih Yang

    (Management Office for Health Data, China Medical University Hospital, Taichung 40402, Taiwan
    College of Medicine, China Medical University, Taichung 40402, Taiwan)

  • Cherry Yin-Yi Chang

    (Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung 40447, Taiwan
    Department of Gynecology, China Medical University Hospital, Taichung 40402, Taiwan)

  • Cheng-Chieh Lin

    (Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung 40447, Taiwan
    Department of Family Medicine, China Medical University Hospital, Taichung 40402, Taiwan)

  • Wu-Huei Hsu

    (Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung 40447, Taiwan
    Department of Chest Medicine, China Medical University Hospital, Taichung 40402, Taiwan)

  • Shu-Woei Ju

    (Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung 40447, Taiwan
    Division of Nephrology and Kidney Institute, China Medical University Hospital, Taichung 40402, Taiwan)

  • Chung-Y. Hsu

    (Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung 40447, Taiwan)

  • Chia-Hung Kao

    (Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung 40447, Taiwan
    Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung 40402, Taiwan
    Department of Bioinformatics and Medical Engineering, Asia University, Taichung, 40402, Taiwan
    Center of Augmented Intelligence in Healthcare, China Medical University Hospital, Taichung, 40402, Taiwan)

Abstract

Background: Air pollutants cause endocrine disorders and hormone disruption. The relationship between air pollutants and polycystic ovary syndrome (PCOS) must be carefully investigated using a nationwide cohort. Methods: Data were extracted from two nationwide databases, namely Longitudinal Health Insurance Database and Taiwan Air Quality Monitoring Database, and analyzed. The study considered a range of data that began on 1 January 2000 and ended on 31 December 2013. Women diagnosed with PCOS were excluded. From the residential data, the study assessed the daily concentrations of sulfur dioxide (SO 2 ), nitrogen oxides (NOx), nitrogen monoxide (NO), nitrogen dioxide (NO 2 ), and PM 2.5 the women were exposed to. A Cox proportional hazard regression model was applied to assess PCOS risk. Results: In total, 91,803 women were enrolled in this study; of those women, 2072 developed PCOS after 12 years of follow-up. The mean daily concentrations of SO 2 , NOx, NO, NO 2 , and PM 2.5 women were exposed to were 4.25 (±1.44) ppb, 20.41 (±6.65) ppb, 9.25 (±4.36) ppb, 20.99 (±3.33) ppb, and 30.85 (±6.16) μg/m 3 , respectively. Compared with the first-quartile levels of exposure, the fourth-quartile levels of exposure to SO 2 , NOx, NO, NO 2 , and PM 2.5 increased PCOS risk by 10.31 times (95% CI = 8.35–12.7), 3.37 times (95% CI = 2.86–3.96), 4.18 times (95% CI = 3.57–4.89), 7.46 times (95% CI = 6.38–8.71), and 3.56 times (95% CI = 3.05–4.15), respectively. Conclusion: Women exposed to a high concentrations of air pollutants, namely SO 2 , NO, NO 2 , NOx, and PM 2.5 , had a high PCOS risk.

Suggested Citation

  • Shih-Yi Lin & Yu-Cih Yang & Cherry Yin-Yi Chang & Cheng-Chieh Lin & Wu-Huei Hsu & Shu-Woei Ju & Chung-Y. Hsu & Chia-Hung Kao, 2019. "Risk of Polycystic Ovary Syndrome in Women Exposed to Fine Air Pollutants and Acidic Gases: A Nationwide Cohort Analysis," IJERPH, MDPI, vol. 16(23), pages 1-14, November.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:23:p:4816-:d:292578
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    References listed on IDEAS

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    1. Yuanyuan Fang & Denise Mauzerall & Junfeng Liu & Arlene Fiore & Larry Horowitz, 2013. "Impacts of 21st century climate change on global air pollution-related premature mortality," Climatic Change, Springer, vol. 121(2), pages 239-253, November.
    2. Shih-Yi Lin & Wu-Huei Hsu & Cheng-Li Lin & Cheng-Chieh Lin & Chih-Hsueh Lin & I-Kuan Wang & Chung-Y. Hsu & Chia-Hung Kao, 2018. "Association of Exposure to Fine-Particulate Air Pollution and Acidic Gases with Incidence of Nephrotic Syndrome," IJERPH, MDPI, vol. 15(12), pages 1-10, December.
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