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Association of Exposure to Fine-Particulate Air Pollution and Acidic Gases with Incidence of Nephrotic Syndrome

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  • Shih-Yi Lin

    (Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, 404 Taichung, Taiwan
    Division of Nephrology and Kidney Institute, China Medical University Hospital, 404 Taichung, Taiwan)

  • Wu-Huei Hsu

    (Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, 404 Taichung, Taiwan
    Department of Chest Medicine, China Medical University Hospital, 404 Taichung, Taiwan)

  • Cheng-Li Lin

    (Management Office for Health Data, China Medical University Hospital, 404 Taichung, Taiwan
    College of Medicine, China Medical University, 404 Taichung, Taiwan)

  • Cheng-Chieh Lin

    (Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, 404 Taichung, Taiwan
    Department of Family Medicine, China Medical University Hospital, 404 Taichung, Taiwan)

  • Chih-Hsueh Lin

    (Department of Geriatrics, China Medical University Hospital, 404 Taichung, Taiwan)

  • I-Kuan Wang

    (Division of Nephrology and Kidney Institute, China Medical University Hospital, 404 Taichung, Taiwan)

  • Chung-Y. Hsu

    (Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, 404 Taichung, Taiwan)

  • Chia-Hung Kao

    (Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, 404 Taichung, Taiwan
    Department of Nuclear Medicine and PET Center, China Medical University Hospital, 404 Taichung, Taiwan
    Department of Bioinformatics and Medical Engineering, Asia University, 413 Taichung, Taiwan)

Abstract

Background : Air pollution has been associated with autoimmune diseases. Nephrotic syndrome is a clinical manifestation of immune-mediated glomerulopathy. However, the association between nephrotic syndrome and air pollution constituents remains unknown. We conducted this nationwide retrospective study to investigate the association between PM 2.5 and nephrotic syndrome. Methods : We used the Longitudinal Health Insurance Database (LHID) and the Taiwan Air Quality-Monitoring Database (TAQMD). We combined and stratified the LHID and the TAQMD data by residential areas of insurants linked to nearby air quality-monitoring stations. Air pollutant concentrations were grouped into four levels based on quartile. Univariable and multivariable Cox proportional hazard regression models were applied. Findings : Relative to Q1-level SO 2 , subjects exposed to the Q4 level were associated with a 2.00-fold higher risk of nephrotic syndrome (adjusted HR = 2.00, 95% CI = 1.66–2.41). In NOx, relative to Q1 NOx concentrations, the adjusted HRs of nephrotic syndrome risk were 1.53 (95% CI = 1.23–1.91), 1.30 (95% CI = 1.03–1.65), and 2.08 (95% CI = 1.69–2.56) for Q2, Q3, and Q4 levels, respectively. The results revealed an increasing trend for nephrotic syndrome risk correlating with increasing levels of NO, NO 2 , and PM 2.5 concentrations. Interpretation : High concentrations of PM 2.5 , NO, NO 2 , and SO 2 are associated with increased risk of nephrotic syndrome.

Suggested Citation

  • Shih-Yi Lin & Wu-Huei Hsu & Cheng-Li Lin & Cheng-Chieh Lin & Chih-Hsueh Lin & I-Kuan Wang & Chung-Y. Hsu & Chia-Hung Kao, 2018. "Association of Exposure to Fine-Particulate Air Pollution and Acidic Gases with Incidence of Nephrotic Syndrome," IJERPH, MDPI, vol. 15(12), pages 1-10, December.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:12:p:2860-:d:190608
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    References listed on IDEAS

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    1. Shih, Yi-Hsuan & Shi, Nian-Xun & Tseng, Chao-Heng & Pan, Shu-Yuan & Chiang, Pen-Chi, 2016. "Socioeconomic costs of replacing nuclear power with fossil and renewable energy in Taiwan," Energy, Elsevier, vol. 114(C), pages 369-381.
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    Cited by:

    1. Shih-Yi Lin & Yu-Cih Yang & Cherry Yin-Yi Chang & Cheng-Chieh Lin & Wu-Huei Hsu & Shu-Woei Ju & Chung-Y. Hsu & Chia-Hung Kao, 2019. "Risk of Polycystic Ovary Syndrome in Women Exposed to Fine Air Pollutants and Acidic Gases: A Nationwide Cohort Analysis," IJERPH, MDPI, vol. 16(23), pages 1-14, November.
    2. Ji-Biao Zhang & Yu-Mei Rong & Qi-Feng Yin & Peng Zhang & Li-Rong Zhao & Chun-Liang Chen, 2022. "Spatiotemporal Variation and Influencing Factors of TSP and Anions in Coastal Atmosphere of Zhanjiang City, China," IJERPH, MDPI, vol. 19(4), pages 1-15, February.

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