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Mortality Due to Cystic Fibrosis over a 36-Year Period in Spain: Time Trends and Geographic Variations

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Listed:
  • Ana Villaverde-Hueso

    (Institute of Rare Diseases Research (IIER), Instituto de Salud Carlos III, 28029 Madrid, Spain
    Centre for Biomedical Network Research on Rare Diseases (CIBERER), 28029 Madrid, Spain)

  • Germán Sánchez-Díaz

    (Institute of Rare Diseases Research (IIER), Instituto de Salud Carlos III, 28029 Madrid, Spain
    Centre for Biomedical Network Research on Rare Diseases (CIBERER), 28029 Madrid, Spain
    Department of Geology, Geography and Environmental Sciences, University of Alcala, 28801 Alcalá de Henares, Spain)

  • Francisco J. Molina-Cabrero

    (Department of Preventive Medicine, Complejo Hospitalario Universitario de Albacete, 02006 Albacete, Spain)

  • Elisa Gallego

    (Department of Preventive Medicine, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain)

  • Manuel Posada de la Paz

    (Institute of Rare Diseases Research (IIER), Instituto de Salud Carlos III, 28029 Madrid, Spain
    Centre for Biomedical Network Research on Rare Diseases (CIBERER), 28029 Madrid, Spain)

  • Verónica Alonso-Ferreira

    (Institute of Rare Diseases Research (IIER), Instituto de Salud Carlos III, 28029 Madrid, Spain
    Centre for Biomedical Network Research on Rare Diseases (CIBERER), 28029 Madrid, Spain)

Abstract

The aim of this study is to analyze population-based mortality attributed to cystic fibrosis (CF) over 36 years in Spain. CF deaths were obtained from the National Statistics Institute, using codes 277.0 from the International Classification of Diseases (ICD) ninth revision (ICD9-CM) and E84 from the tenth revision (ICD10) to determine the underlying cause of death. We calculated age-specific and age-adjusted mortality rates, and time trends were assessed using joinpoint regression. The geographic analysis by district was performed by standardized mortality ratios (SMRs) and smoothed-SMRs. A total of 1002 deaths due to CF were identified (50.5% women). Age-adjusted mortality rates fell by −0.95% per year between 1981 and 2016. The average age of death from CF increased due to the annual fall in the mortality of under-25s (−3.77% males, −2.37% females) and an increase in over-75s (3.49%). We identified districts with higher than expected death risks in the south (Andalusia), the Mediterranean coast (Murcia, Valencia, Catalonia), the West (Extremadura), and the Canary Islands. In conclusion, in this study we monitored the population-based mortality attributed to CF over a long period and found geographic differences in the risk of dying from this disease. These findings complement the information provided in other studies and registries and will be useful for health planning.

Suggested Citation

  • Ana Villaverde-Hueso & Germán Sánchez-Díaz & Francisco J. Molina-Cabrero & Elisa Gallego & Manuel Posada de la Paz & Verónica Alonso-Ferreira, 2019. "Mortality Due to Cystic Fibrosis over a 36-Year Period in Spain: Time Trends and Geographic Variations," IJERPH, MDPI, vol. 16(1), pages 1-12, January.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:1:p:119-:d:194929
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    References listed on IDEAS

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    1. Verónica Alonso-Ferreira & Germán Sánchez-Díaz & Ana Villaverde-Hueso & Manuel Posada de la Paz & Eva Bermejo-Sánchez, 2018. "A Nationwide Registry-Based Study on Mortality Due to Rare Congenital Anomalies," IJERPH, MDPI, vol. 15(8), pages 1-20, August.
    2. Julian Besag & Jeremy York & Annie Mollié, 1991. "Bayesian image restoration, with two applications in spatial statistics," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 43(1), pages 1-20, March.
    3. Anna Zolin & Anna Bossi & Natalia Cirilli & Nataliya Kashirskaya & Rita Padoan, 2018. "Cystic Fibrosis Mortality in Childhood. Data from European Cystic Fibrosis Society Patient Registry," IJERPH, MDPI, vol. 15(9), pages 1-11, September.
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    1. Marta Rachel & Stanisław Topolewicz & Andrzej Śliwczyński & Sabina Galiniak, 2020. "Managing Cystic Fibrosis in Polish Healthcare," IJERPH, MDPI, vol. 17(20), pages 1-17, October.

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