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Memory Function, Neurological, and Immunological Biomarkers in Allergic Asthmatic Mice Intratracheally Exposed to Bisphenol A

Author

Listed:
  • Tin-Tin Win-Shwe

    (Center for Health and Environmental Risk Research, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan)

  • Rie Yanagisawa

    (Center for Health and Environmental Risk Research, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan)

  • Eiko Koike

    (Center for Health and Environmental Risk Research, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan)

  • Hirohisa Takano

    (Environmental Health Sciences, Graduate School of Global Environmental Studies, Kyoto University, Kyoto 615-8540, Japan)

Abstract

Bisphenol A (BPA) is a major constituent of plastic products, including epoxy resin containers, mobile phones, dental sealants, as well as electronic and medical equipment. BPA is recognized as an endocrine system-disrupting chemical which has toxic effects on the brain and reproductive system. However, little is known about the effects of co-exposure of BPA with allergens on the memory function and neurological as well as immunological biomarker levels. In this study, we examined the effects of intratracheal instillation of BPA on the memory function and neuroimmune biomarker levels using a mouse model of allergic asthma. Male C3H/HeJ Jcl mice were given three doses of BPA (0.0625 pmol, 1.25 pmol, and 25 pmol BPA/animal) intratracheally once a week, and ovalbumin (OVA) intratracheally every other week from 5 to 11 weeks old. At 11 weeks of age, a novel object recognition test was conducted after the final administration of OVA, and the hippocampi and hypothalami of the animals were collected after 24 h. The expression levels of the memory function-related genes N-methyl-D-aspartate (NMDA) receptor subunits, inflammatory cytokines, microglia markers, estrogen receptor-alpha, and oxytocin receptor were examined by real-time RT-PCR (real-time reverse transcription polymerase chain reaction) and immunohistochemical methods. Impairment of the novel object recognition ability was observed in the high-dose BPA-exposed mice with allergic asthma. In addition, the allergic asthmatic mice also showed downregulation of neurological biomarkers, such as NMDA receptor subunit NR2B in the hippocampus but no significant effect on immunological biomarkers in the hypothalamus. These findings suggest that exposure to high-dose BPA triggered impairment of memory function in the allergic asthmatic mice. This is the first study to show that, in the presence of allergens, exposure to high-dose BPA may affect memory by modulating the memory function-related genes in the hippocampus.

Suggested Citation

  • Tin-Tin Win-Shwe & Rie Yanagisawa & Eiko Koike & Hirohisa Takano, 2019. "Memory Function, Neurological, and Immunological Biomarkers in Allergic Asthmatic Mice Intratracheally Exposed to Bisphenol A," IJERPH, MDPI, vol. 16(19), pages 1-16, October.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:19:p:3770-:d:274074
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    References listed on IDEAS

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    1. Tin-Tin Win-Shwe & Yuji Fujitani & Chaw Kyi-Tha-Thu & Akiko Furuyama & Takehiro Michikawa & Shinji Tsukahara & Hiroshi Nitta & Seishiro Hirano, 2014. "Effects of Diesel Engine Exhaust Origin Secondary Organic Aerosols on Novel Object Recognition Ability and Maternal Behavior in BALB/C Mice," IJERPH, MDPI, vol. 11(11), pages 1-22, October.
    2. Jaakkola, J.J.K. & Øie, L. & Nafstad, P. & Botten, G. & Samuelsen, S.O. & Magnus, P., 1999. "Interior surface materials in the home and the development of bronchial obstruction in young children in Oslo, Norway," American Journal of Public Health, American Public Health Association, vol. 89(2), pages 188-192.
    3. Yumin Zhang & Gang Liu & Jingqi Yan & Yalin Zhang & Bo Li & Dongsheng Cai, 2015. "Metabolic learning and memory formation by the brain influence systemic metabolic homeostasis," Nature Communications, Nature, vol. 6(1), pages 1-13, November.
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