Author
Listed:
- Renata E. Howland
(Department of Epidemiology, Mailman School of Public Health, New York, NY 10032, USA)
- Nicole C. Deziel
(Yale School of Public Health, Yale University, New Haven, CT 06510, USA
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethseda, MD 20892, USA)
- Gillian R. Bentley
(Department of Anthropology, Durham University, Durham DH13LE, UK)
- Mark Booth
(Faculty of Medical Sciences, Newcastle University, Newcastle NE24HH, UK)
- Osul A. Choudhury
(Sylhet MAG Osmani Medical College, Sylhet WV23JH, Bangladesh)
- Jonathan N. Hofmann
(Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethseda, MD 20892, USA)
- Robert N. Hoover
(Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethseda, MD 20892, USA)
- Hormuzd A. Katki
(Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethseda, MD 20892, USA)
- Britton Trabert
(Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethseda, MD 20892, USA)
- Stephen D. Fox
(Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA)
- Rebecca Troisi
(Faculty of Medical Sciences, Newcastle University, Newcastle NE24HH, UK)
- Lauren C. Houghton
(Department of Epidemiology, Mailman School of Public Health, New York, NY 10032, USA)
Abstract
Timing of breast development (or thelarche) and its endogenous and exogenous determinants may underlie global variation in breast cancer incidence. The study objectives were to characterize endogenous estrogen levels and bisphenol A (BPA) exposure using a migrant study of adolescent girls and test whether concentrations explained differences in thelarche by birthplace and growth environment. Estrogen metabolites (EM) and BPA-glucuronide (BPA-G) were quantified in urine spot samples using liquid chromatography tandem mass spectrometry (LC-MS/MS) from a cross-sectional study of Bangladeshi, first- and second-generation Bangladeshi migrants to the UK, and white British girls aged 5–16 years ( n = 348). Thelarche status at the time of interview was self-reported and defined equivalent to Tanner Stage ≥2. We compared geometric means (and 95% confidence interval (CIs)) of EM and BPA-G using linear regression and assessed whether EM and BPA-G explained any of the association between exposure to the UK and the age at thelarche using hazard ratios and 95% confidence intervals. Average EM decreased with exposure to the UK, whereas BPA-G increased and was significantly higher among white British (0.007 ng/mL, 95% CI: 0.0024–0.0217) and second-generation British-Bangladeshi girls (0.009 ng/mL, 95% CI: 0.0040–0.0187) compared to Bangladeshi girls (0.002 ng/mL, 95% CI: 0.0018–0.0034). Two of four EM ratios (16-pathway/parent and parent/all pathways) were significantly associated with thelarche. The relationship between exposure to the UK and thelarche did not change appreciably after adding EM and BPA-G to the models. While BPA-G is often considered a ubiquitous exposure, our findings suggest it can vary based on birthplace and growth environment, with increasing levels for girls who were born in or moved to the UK. Our study did not provide statistically significant evidence that BPA-G or EM concentrations explained earlier thelarche among girls who were born or raised in the UK.
Suggested Citation
Renata E. Howland & Nicole C. Deziel & Gillian R. Bentley & Mark Booth & Osul A. Choudhury & Jonathan N. Hofmann & Robert N. Hoover & Hormuzd A. Katki & Britton Trabert & Stephen D. Fox & Rebecca Troi, 2020.
"Assessing Endogenous and Exogenous Hormone Exposures and Breast Development in a Migrant Study of Bangladeshi and British Girls,"
IJERPH, MDPI, vol. 17(4), pages 1-12, February.
Handle:
RePEc:gam:jijerp:v:17:y:2020:i:4:p:1185-:d:319942
Download full text from publisher
References listed on IDEAS
- Alejandra Núñez-de la Mora & Robert T Chatterton & Osul A Choudhury & Dora A Napolitano & Gillian R Bentley, 2007.
"Childhood Conditions Influence Adult Progesterone Levels,"
PLOS Medicine, Public Library of Science, vol. 4(5), pages 1-9, May.
- Patrick Royston, 2004.
"Flexible parametric alternatives to the Cox model: update,"
Stata Journal, StataCorp LP, vol. 4(1), pages 98-101, March.
- Alberto Leonardi & Marta Cofini & Donato Rigante & Laura Lucchetti & Clelia Cipolla & Laura Penta & Susanna Esposito, 2017.
"The Effect of Bisphenol A on Puberty: A Critical Review of the Medical Literature,"
IJERPH, MDPI, vol. 14(9), pages 1-20, September.
Full references (including those not matched with items on IDEAS)
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2020:i:4:p:1185-:d:319942. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .
Please note that corrections may take a couple of weeks to filter through
the various RePEc services.