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Benzene Exposure Alters Expression of Enzymes Involved in Fatty Acid β-Oxidation in Male C3H/He Mice

Author

Listed:
  • Rongli Sun

    (Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China
    These authors contributed equally to this work.)

  • Meng Cao

    (Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China
    These authors contributed equally to this work.)

  • Juan Zhang

    (Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China)

  • Wenwen Yang

    (Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China)

  • Haiyan Wei

    (Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China)

  • Xing Meng

    (Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China)

  • Lihong Yin

    (Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China)

  • Yuepu Pu

    (Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China)

Abstract

Benzene is a well-known hematotoxic carcinogen that can cause leukemia and a variety of blood disorders. Our previous study indicated that benzene disturbs levels of metabolites in the fatty acid β-oxidation (FAO) pathway, which is crucial for the maintenance and function of hematopoietic and leukemic cells. The present research aims to investigate the effects of benzene on changes in the expression of key enzymes in the FAO pathway in male C3H/He mice. Results showed that benzene exposure caused reduced peripheral white blood cell (WBC), red blood cell (RBC), platelet (Pit) counts, and hemoglobin (Hgb) concentration. Investigation of the effects of benzene on the expression of FA transport- and β-oxidation-related enzymes showed that expression of proteins Cpt1a, Crat, Acaa2, Aldh1l2, Acadvl, Crot, Echs1, and Hadha was significantly increased. The ATP levels and mitochondrial membrane potential decreased in mice exposed to benzene. Meanwhile, reactive oxygen species (ROS), hydrogen peroxide (H 2 O 2 ), and malondialdehyde (MDA) levels were significantly increased in the benzene group. Our results indicate that benzene induces increased expression of FA transport and β-oxidation enzymes, mitochondrial dysfunction, and oxidative stress, which may play a role in benzene-induced hematotoxicity.

Suggested Citation

  • Rongli Sun & Meng Cao & Juan Zhang & Wenwen Yang & Haiyan Wei & Xing Meng & Lihong Yin & Yuepu Pu, 2016. "Benzene Exposure Alters Expression of Enzymes Involved in Fatty Acid β-Oxidation in Male C3H/He Mice," IJERPH, MDPI, vol. 13(11), pages 1-11, October.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:11:p:1068-:d:81821
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    References listed on IDEAS

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    1. Zachary T. Schafer & Alexandra R. Grassian & Loling Song & Zhenyang Jiang & Zachary Gerhart-Hines & Hanna Y. Irie & Sizhen Gao & Pere Puigserver & Joan S. Brugge, 2009. "Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment," Nature, Nature, vol. 461(7260), pages 109-113, September.
    2. Rongli Sun & Juan Zhang & Mengzhen Xiong & Haiyan Wei & Kehong Tan & Lihong Yin & Yuepu Pu, 2015. "Altered Expression of Genes in Signaling Pathways Regulating Proliferation of Hematopoietic Stem and Progenitor Cells in Mice with Subchronic Benzene Exposure," IJERPH, MDPI, vol. 12(8), pages 1-16, August.
    3. Sang-Min Jeon & Navdeep S. Chandel & Nissim Hay, 2012. "AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress," Nature, Nature, vol. 485(7400), pages 661-665, May.
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    Cited by:

    1. Ramya Dewi Mathialagan & Zariyantey Abd Hamid & Qing Min Ng & Nor Fadilah Rajab & Salwati Shuib & Siti Razila Binti Abdul Razak, 2020. "Bone Marrow Oxidative Stress and Acquired Lineage-Specific Genotoxicity in Hematopoietic Stem/Progenitor Cells Exposed to 1,4-Benzoquinone," IJERPH, MDPI, vol. 17(16), pages 1-15, August.

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