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AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

Author

Listed:
  • Sang-Min Jeon

    (College of Medicine, University of Illinois at Chicago
    Present address: Research Oncology, Genentech, South San Francisco, California 94080, USA)

  • Navdeep S. Chandel

    (Northwestern University Medical School)

  • Nissim Hay

    (College of Medicine, University of Illinois at Chicago)

Abstract

A mechanism is suggested that helps tumour cells survive energy stress conditions during early stages of tumorigenesis.

Suggested Citation

  • Sang-Min Jeon & Navdeep S. Chandel & Nissim Hay, 2012. "AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress," Nature, Nature, vol. 485(7400), pages 661-665, May.
    • Handle: RePEc:nat:nature:v:485:y:2012:i:7400:d:10.1038_nature11066
    DOI: 10.1038/nature11066
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    Cited by:

    1. Rongli Sun & Meng Cao & Juan Zhang & Wenwen Yang & Haiyan Wei & Xing Meng & Lihong Yin & Yuepu Pu, 2016. "Benzene Exposure Alters Expression of Enzymes Involved in Fatty Acid β-Oxidation in Male C3H/He Mice," IJERPH, MDPI, vol. 13(11), pages 1-11, October.
    2. Tal Levy & Kai Voeltzke & Laura Hruby & Khawla Alasad & Zuelal Bas & Marteinn Snaebjörnsson & Ran Marciano & Katerina Scharov & Mélanie Planque & Kim Vriens & Stefan Christen & Cornelius M. Funk & Chr, 2024. "mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Ipshita Nandi & Linjia Ji & Harvey W. Smith & Daina Avizonis & Vasilios Papavasiliou & Cynthia Lavoie & Alain Pacis & Sherif Attalla & Virginie Sanguin-Gendreau & William J. Muller, 2024. "Targeting fatty acid oxidation enhances response to HER2-targeted therapy," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    4. Ji-Man Park & Da-Hye Lee & Do-Hyung Kim, 2023. "Redefining the role of AMPK in autophagy and the energy stress response," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    5. Héctor García Martín & Vinay Satish Kumar & Daniel Weaver & Amit Ghosh & Victor Chubukov & Aindrila Mukhopadhyay & Adam Arkin & Jay D Keasling, 2015. "A Method to Constrain Genome-Scale Models with 13C Labeling Data," PLOS Computational Biology, Public Library of Science, vol. 11(9), pages 1-34, September.
    6. Wei Liu & Hongchao Cao & Jing Wang & Areeg Elmusrati & Bing Han & Wei Chen & Ping Zhou & Xiyao Li & Stephen Keysar & Antonio Jimeno & Cun-Yu Wang, 2024. "Histone-methyltransferase KMT2D deficiency impairs the Fanconi anemia/BRCA pathway upon glycolytic inhibition in squamous cell carcinoma," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    7. Jayaraman, K. & Paramasivan, Lavinsaa & Kiumarsi, Shaian, 2017. "Reasons for low penetration on the purchase of photovoltaic (PV) panel system among Malaysian landed property owners," Renewable and Sustainable Energy Reviews, Elsevier, vol. 80(C), pages 562-571.

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