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Serum Biomarkers of Exposure to Perfluoroalkyl Substances in Relation to Serum Testosterone and Measures of Thyroid Function among Adults and Adolescents from NHANES 2011–2012

Author

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  • Ryan C. Lewis

    (Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA)

  • Lauren E. Johns

    (Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA)

  • John D. Meeker

    (Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA)

Abstract

Perfluoroalkyl substances (PFASs) are a group of environmentally-persistent chemicals that have been widely used in many industrial applications. There is human and animal evidence that PFASs may alter levels of reproductive and thyroid-related hormones. However, human studies on the potential age-related effects of PFASs on these outcomes among males and females are limited. We explored the relationship between serum PFASs and serum total testosterone (T), thyroid stimulating hormone (TSH), and free and total triiodothyronine (FT3, TT3) and thyroxine (FT4, TT4) among males and females 12 to 80 years of age from the 2011–2012 cycle of the National Health and Nutrition Examination Survey. Associations were assessed using multiple linear regression models that were stratified on sex and age categories. Effect estimates from the majority of the adjusted models were not statistically significant. However, exposure to PFASs may be associated with increases in FT3, TT3, and FT4 among adult females, but during adolescence, PFASs may be related to increases in TSH among males and decreases in TSH among females. No significant relationships were observed between PFASs and T in any of the models. These findings suggest that exposure to PFASs may disrupt thyroid hormone homeostasis.

Suggested Citation

  • Ryan C. Lewis & Lauren E. Johns & John D. Meeker, 2015. "Serum Biomarkers of Exposure to Perfluoroalkyl Substances in Relation to Serum Testosterone and Measures of Thyroid Function among Adults and Adolescents from NHANES 2011–2012," IJERPH, MDPI, vol. 12(6), pages 1-17, May.
    • Handle: RePEc:gam:jijerp:v:12:y:2015:i:6:p:6098-6114:d:50361
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    References listed on IDEAS

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    1. Korn, E.L. & Graubard, B.I., 1991. "Epidemiologic studies utilizing surveys: Accounting for the sampling design," American Journal of Public Health, American Public Health Association, vol. 81(9), pages 1166-1173.
    2. Kim, Jaehoon & Kim, Sangsin, 2015. "2012년 국회법 개정의 효과 연구 [A Study on the Effect of the 2012 National Assembly Act Amendment]," KDI Research Monographs, Korea Development Institute (KDI), volume 127, number v:2015-03(k):y:2015:p:1-1.
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    Cited by:

    1. Pheruza Tarapore & Bin Ouyang, 2021. "Perfluoroalkyl Chemicals and Male Reproductive Health: Do PFOA and PFOS Increase Risk for Male Infertility?," IJERPH, MDPI, vol. 18(7), pages 1-20, April.
    2. Nicole Marie Brennan & Abigail Teresa Evans & Meredith Kate Fritz & Stephanie Allison Peak & Haley Elizabeth von Holst, 2021. "Trends in the Regulation of Per- and Polyfluoroalkyl Substances (PFAS): A Scoping Review," IJERPH, MDPI, vol. 18(20), pages 1-28, October.
    3. Judy Yan & Michael A. Joseph & Simone A. Reynolds & Laura A. Geer, 2020. "Association between Urinary Triclosan and Serum Testosterone Levels in U.S. Adult Males from NHANES, 2011–2012," IJERPH, MDPI, vol. 17(20), pages 1-9, October.
    4. Andrea B. Kirk & Kelsey Marie Plasse & Karli C. Kirk & Clyde F. Martin & Gamze Ozsoy, 2022. "Predicting Exposure to Perfluorinated Alkyl Substances (PFAS) among US Infants," IJERPH, MDPI, vol. 19(14), pages 1-16, July.

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