IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i14p8402-d859206.html
   My bibliography  Save this article

Predicting Exposure to Perfluorinated Alkyl Substances (PFAS) among US Infants

Author

Listed:
  • Andrea B. Kirk

    (Milken Institute School of Public Health, George Washington University, Washington, DC 20052, USA)

  • Kelsey Marie Plasse

    (Department of Chemistry, Miami University, Oxford, OH 45056, USA)

  • Karli C. Kirk

    (Department of Computer Science, University of Texas at Austin, Austin, TX 78712, USA)

  • Clyde F. Martin

    (Department of Mathematics and Statistics, Texas Tech University, Lubbock, TX 79409, USA)

  • Gamze Ozsoy

    (Department of Pediatrics, Georgetown University School of Medicine, Washington, DC 20007, USA)

Abstract

PFASs have been detected in nearly every serum sample collected over the last two decades from US adults as part of the National Health and Nutrition Examination Survey (NHANES) and are commonly found in other data sets from around the world. However, less is known about infant PFAS exposures, primarily because the collection of infant serum samples is less common and frequently avoided. Cord blood samples are often preferred for chemical exposure assessments because this is thought to provide a good representation of infant serum concentrations, at least at the time of birth. In this paper, we will provide a statistical and probabilistic analysis of what can be expected for infants living in the US using NHANES from 2007 to 2008, which contains a rare subset of infant data. Regulatory efforts that require estimation of exposures among the very youth can be challenging, both because of a lack of data in general and because variability among this most vulnerable population can be uncertain. We report that US infant exposures are extremely common and that serum concentrations remain fairly constant, despite infant growth rates and relatively high caloric and fluid intake, with the possible exception of PFOS. Infant serum PFOS concentrations between months 1 and 3 are consistently higher than at less than one month, even though healthy infants at 1 and 2 months weigh more than they did at birth. This suggests that the babies are exposed to greater concentrations of PFOS after birth or that excretion kinetics differ for this PFAS.

Suggested Citation

  • Andrea B. Kirk & Kelsey Marie Plasse & Karli C. Kirk & Clyde F. Martin & Gamze Ozsoy, 2022. "Predicting Exposure to Perfluorinated Alkyl Substances (PFAS) among US Infants," IJERPH, MDPI, vol. 19(14), pages 1-16, July.
  • Handle: RePEc:gam:jijerp:v:19:y:2022:i:14:p:8402-:d:859206
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/14/8402/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/19/14/8402/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. David Trudel & Lea Horowitz & Matthias Wormuth & Martin Scheringer & Ian T. Cousins & Konrad Hungerbühler, 2008. "Estimating Consumer Exposure to PFOS and PFOA," Risk Analysis, John Wiley & Sons, vol. 28(2), pages 251-269, April.
    2. Ilona Quaak & Marijke De Cock & Michiel De Boer & Marja Lamoree & Pim Leonards & Margot Van de Bor, 2016. "Prenatal Exposure to Perfluoroalkyl Substances and Behavioral Development in Children," IJERPH, MDPI, vol. 13(5), pages 1-20, May.
    3. Ryan C. Lewis & Lauren E. Johns & John D. Meeker, 2015. "Serum Biomarkers of Exposure to Perfluoroalkyl Substances in Relation to Serum Testosterone and Measures of Thyroid Function among Adults and Adolescents from NHANES 2011–2012," IJERPH, MDPI, vol. 12(6), pages 1-17, May.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yuxuan Tan & Zurui Zeng & Huanzhu Liang & Xueqiong Weng & Huojie Yao & Yingyin Fu & Yexin Li & Jingmin Chen & Xiangcai Wei & Chunxia Jing, 2022. "Association between Perfluoroalkyl and Polyfluoroalkyl Substances and Women’s Infertility, NHANES 2013–2016," IJERPH, MDPI, vol. 19(22), pages 1-15, November.
    2. Andrea B. Kirk & Alisa DeStefano & Alexander Martin & Karli C. Kirk & Clyde F. Martin, 2023. "A New Interpretation of Relative Importance on an Analysis of Per and Polyfluorinated Alkyl Substances (PFAS) Exposures on Bone Mineral Density," IJERPH, MDPI, vol. 20(5), pages 1-19, March.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Huojie Yao & Yingyin Fu & Xueqiong Weng & Zurui Zeng & Yuxuan Tan & Xiaomei Wu & Huixian Zeng & Zhiyu Yang & Yexin Li & Huanzhu Liang & Yingying Wu & Lin Wen & Chunxia Jing, 2023. "The Association between Prenatal Per- and Polyfluoroalkyl Substances Exposure and Neurobehavioral Problems in Offspring: A Meta-Analysis," IJERPH, MDPI, vol. 20(3), pages 1-16, January.
    2. Nilisha Khadgi Sonnenberg & Akinloye Emmanuel Ojewole & Catherine Oluwalopeye Ojewole & Otite Precious Lucky & Joseph Kusi, 2023. "Trends in Serum Per- and Polyfluoroalkyl Substance (PFAS) Concentrations in Teenagers and Adults, 1999–2018 NHANES," IJERPH, MDPI, vol. 20(21), pages 1-14, October.
    3. Judy Yan & Michael A. Joseph & Simone A. Reynolds & Laura A. Geer, 2020. "Association between Urinary Triclosan and Serum Testosterone Levels in U.S. Adult Males from NHANES, 2011–2012," IJERPH, MDPI, vol. 17(20), pages 1-9, October.
    4. Blake Langenbach & Mark Wilson, 2021. "Per- and Polyfluoroalkyl Substances (PFAS): Significance and Considerations within the Regulatory Framework of the USA," IJERPH, MDPI, vol. 18(21), pages 1-17, October.
    5. Meng-Shan Tsai & Chihiro Miyashita & Atsuko Araki & Sachiko Itoh & Yu Ait Bamai & Houman Goudarzi & Emiko Okada & Ikuko Kashino & Hideyuki Matsuura & Reiko Kishi, 2018. "Determinants and Temporal Trends of Perfluoroalkyl Substances in Pregnant Women: The Hokkaido Study on Environment and Children’s Health," IJERPH, MDPI, vol. 15(5), pages 1-14, May.
    6. Charlotte Stübner & Christel Nielsen & Kristina Jakobsson & Christopher Gillberg & Carmela Miniscalco, 2023. "Early-Life Exposure to Perfluoroalkyl Substances (PFAS) and Child Language and Communication Development: A Systematic Review," IJERPH, MDPI, vol. 20(24), pages 1-20, December.
    7. Natalie Von Goetz & Matthias Wormuth & Martin Scheringer & Konrad Hungerbühler, 2010. "Bisphenol A: How the Most Relevant Exposure Sources Contribute to Total Consumer Exposure," Risk Analysis, John Wiley & Sons, vol. 30(3), pages 473-487, March.
    8. Kristen M. Rappazzo & Evan Coffman & Erin P. Hines, 2017. "Exposure to Perfluorinated Alkyl Substances and Health Outcomes in Children: A Systematic Review of the Epidemiologic Literature," IJERPH, MDPI, vol. 14(7), pages 1-22, June.
    9. Nicole Marie Brennan & Abigail Teresa Evans & Meredith Kate Fritz & Stephanie Allison Peak & Haley Elizabeth von Holst, 2021. "Trends in the Regulation of Per- and Polyfluoroalkyl Substances (PFAS): A Scoping Review," IJERPH, MDPI, vol. 18(20), pages 1-28, October.
    10. Pheruza Tarapore & Bin Ouyang, 2021. "Perfluoroalkyl Chemicals and Male Reproductive Health: Do PFOA and PFOS Increase Risk for Male Infertility?," IJERPH, MDPI, vol. 18(7), pages 1-20, April.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:14:p:8402-:d:859206. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.