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Indoor and Outdoor Exposure to Ultrafine, Fine and Microbiologically Derived Particulate Matter Related to Cardiovascular and Respiratory Effects in a Panel of Elderly Urban Citizens

Author

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  • Dorina Gabriela Karottki

    (Section of Environmental Health, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Øster Farimagsgade 5, DK-1014, Copenhagen, Denmark)

  • Michal Spilak

    (Danish Building Research Institute, Department of Construction and Health, Aalborg University, Copenhagen, Denmark)

  • Marie Frederiksen

    (Danish Building Research Institute, Department of Construction and Health, Aalborg University, Copenhagen, Denmark)

  • Zorana Jovanovic Andersen

    (Center for Epidemiology and Screening, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Øster Farimagsgade 5, DK-1014 Copenhagen, Denmark)

  • Anne Mette Madsen

    (National Research Centre for the Working Environment, Lersø Parkallé 105, 2100 Copenhagen, Denmark)

  • Matthias Ketzel

    (Department of Environmental Science, Aarhus University, Frederiksborgvej 399, 4000 Roskilde, Denmark)

  • Andreas Massling

    (Department of Environmental Science, Aarhus University, Frederiksborgvej 399, 4000 Roskilde, Denmark)

  • Lars Gunnarsen

    (Danish Building Research Institute, Department of Construction and Health, Aalborg University, Copenhagen, Denmark)

  • Peter Møller

    (Section of Environmental Health, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Øster Farimagsgade 5, DK-1014, Copenhagen, Denmark)

  • Steffen Loft

    (Section of Environmental Health, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Øster Farimagsgade 5, DK-1014, Copenhagen, Denmark)

Abstract

To explore associations of exposure to ambient and indoor air particulate and bio-aerosol pollutants with cardiovascular and respiratory disease markers, we utilized seven repeated measurements from 48 elderly subjects participating in a 4-week home air filtration study. Microvascular function (MVF), lung function, blood leukocyte counts, monocyte adhesion molecule expression, C-reactive protein, Clara cell protein (CC16) and surfactant protein-D (SPD) were examined in relation to exposure preceding each measurement. Exposure assessment included 48-h urban background monitoring of PM 10 , PM 2.5 and particle number concentration (PNC), weekly measurements of PM 2.5 in living- and bedroom, 24-h measurements of indoor PNC three times, and bio-aerosol components in settled dust on a 2-week basis. Statistically significant inverse associations included: MVF with outdoor PNC; granulocyte counts with PM 2.5 ; CD31 expression with dust fungi; SPD with dust endotoxin. Significant positive associations included: MVF with dust bacteria; monocyte expression of CD11 with PM 2.5 in the bedroom and dust bacteria and endotoxin, CD31 expression with dust serine protease; serum CC16 with dust NAGase. Multiple comparisons demand cautious interpretation of results, which suggest that outdoor PNC have adverse effects on MVF, and outdoor and indoor PM 2.5 and bio-aerosols are associated with markers of inflammation and lung cell integrity.

Suggested Citation

  • Dorina Gabriela Karottki & Michal Spilak & Marie Frederiksen & Zorana Jovanovic Andersen & Anne Mette Madsen & Matthias Ketzel & Andreas Massling & Lars Gunnarsen & Peter Møller & Steffen Loft, 2015. "Indoor and Outdoor Exposure to Ultrafine, Fine and Microbiologically Derived Particulate Matter Related to Cardiovascular and Respiratory Effects in a Panel of Elderly Urban Citizens," IJERPH, MDPI, vol. 12(2), pages 1-20, February.
    • Handle: RePEc:gam:jijerp:v:12:y:2015:i:2:p:1667-1686:d:45391
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    References listed on IDEAS

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    1. Vanessa J. Soppa & Roel P. F. Schins & Frauke Hennig & Bryan Hellack & Ulrich Quass & Heinz Kaminski & Thomas A. J. Kuhlbusch & Barbara Hoffmann & Gudrun Weinmayr, 2014. "Respiratory Effects of Fine and Ultrafine Particles from Indoor Sources—A Randomized Sham-Controlled Exposure Study of Healthy Volunteers," IJERPH, MDPI, vol. 11(7), pages 1-19, July.
    2. Peter Libby, 2002. "Inflammation in atherosclerosis," Nature, Nature, vol. 420(6917), pages 868-874, December.
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    2. Yufei Yuan & Barrak Alahmad & Choong-Min Kang & Fhaid Al-Marri & Venkateswarlu Kommula & Walid Bouhamra & Petros Koutrakis, 2020. "Dust Events and Indoor Air Quality in Residential Homes in Kuwait," IJERPH, MDPI, vol. 17(7), pages 1-12, April.
    3. Karina Camasmie Abe & Simone Georges El Khouri Miraglia, 2016. "Health Impact Assessment of Air Pollution in São Paulo, Brazil," IJERPH, MDPI, vol. 13(7), pages 1-10, July.
    4. Sotiris Vardoulakis & Evanthia Giagloglou & Susanne Steinle & Alice Davis & Anne Sleeuwenhoek & Karen S. Galea & Ken Dixon & Joanne O. Crawford, 2020. "Indoor Exposure to Selected Air Pollutants in the Home Environment: A Systematic Review," IJERPH, MDPI, vol. 17(23), pages 1-24, December.
    5. Bo Hong & Hongqiao Qin & Runsheng Jiang & Min Xu & Jiaqi Niu, 2018. "How Outdoor Trees Affect Indoor Particulate Matter Dispersion: CFD Simulations in a Naturally Ventilated Auditorium," IJERPH, MDPI, vol. 15(12), pages 1-21, December.
    6. Tianhao Zhang & Zhongmin Zhu & Wei Gong & Hao Xiang & Ruimin Fang, 2016. "Characteristics of Fine Particles in an Urban Atmosphere—Relationships with Meteorological Parameters and Trace Gases," IJERPH, MDPI, vol. 13(8), pages 1-16, August.
    7. Hanns Moshammer & Julian Panholzer & Lisa Ulbing & Emanuel Udvarhelyi & Barbara Ebenbauer & Stefanie Peter, 2019. "Acute Effects of Air Pollution and Noise from Road Traffic in a Panel of Young Healthy Adults," IJERPH, MDPI, vol. 16(5), pages 1-16, March.

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