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Exposure to Endocrine Disrupters and Nuclear Receptor Gene Expression in Infertile and Fertile Women from Different Italian Areas

Author

Listed:
  • Cinzia La Rocca

    (Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, Roma 00161, Italy)

  • Sabrina Tait

    (Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, Roma 00161, Italy)

  • Cristiana Guerranti

    (Department of Physical, Earth and Environmental Sciences, University of Siena, Siena 53100, Italy
    Institute of Clinical Physiology, National Research Council, Pisa 73100, Italy)

  • Luca Busani

    (Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, Roma 00161, Italy)

  • Francesca Ciardo

    (Department of Obstetric and Gynecological Sciences and Urological Sciences, University of Roma Sapienza, S. Andrea Hospital, Roma 00189, Italy)

  • Bruno Bergamasco

    (Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, Roma 00161, Italy)

  • Laura Stecca

    (Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, Roma 00161, Italy)

  • Guido Perra

    (Department of Physical, Earth and Environmental Sciences, University of Siena, Siena 53100, Italy)

  • Francesca Romana Mancini

    (Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, Roma 00161, Italy
    Department of Veterinary Medicine, University of Bologna, Ozzano dell'Emilia 40064, Italy)

  • Roberto Marci

    (Department of Biomedical Sciences and Advanced Therapies, Section of Obstetrics and Gynaecology, University of Ferrara, Ferrara 44121, Italy)

  • Giulia Bordi

    (Department of Obstetric and Gynecological Sciences and Urological Sciences, University of Roma Sapienza, S. Andrea Hospital, Roma 00189, Italy)

  • Donatella Caserta

    (Department of Obstetric and Gynecological Sciences and Urological Sciences, University of Roma Sapienza, S. Andrea Hospital, Roma 00189, Italy)

  • Silvano Focardi

    (Department of Physical, Earth and Environmental Sciences, University of Siena, Siena 53100, Italy)

  • Massimo Moscarini

    (Department of Obstetric and Gynecological Sciences and Urological Sciences, University of Roma Sapienza, S. Andrea Hospital, Roma 00189, Italy)

  • Alberto Mantovani

    (Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, Roma 00161, Italy)

Abstract

Within the PREVIENI project, infertile and fertile women were enrolled from metropolitan, urban and rural Italian areas. Blood/serum levels of several endocrine disrupters (EDs) (perfluorooctane sulfonate, PFOS; perfluorooctanoic acid, PFOA; di-2-ethylhexyl-phthalate, DEHP; mono-(2-ethylhexyl)-phthalate, MEHP; bisphenol A, BPA) were evaluated concurrently with nuclear receptors (NRs) gene expression levels (ERa, ERb, AR, AhR, PPARg, PXR) in peripheral blood mononuclear cells (PBMCs). Infertile women from the metropolitan area displayed significantly higher levels of: BPA compared to fertile women (14.9 vs. 0.5 ng/mL serum); BPA and MEHP compared to infertile women from urban and rural areas; enhanced expression levels of NRs, except PPARg. Infertile women from urban and rural areas had PFOA levels significantly higher than those from metropolitan areas. Our study indicates the relevance of the living environment when investigating the exposure to EDs and the modulation of the NR panel in PBMC as a suitable biomarker of the effect, to assess the EDs impact on reproductive health.

Suggested Citation

  • Cinzia La Rocca & Sabrina Tait & Cristiana Guerranti & Luca Busani & Francesca Ciardo & Bruno Bergamasco & Laura Stecca & Guido Perra & Francesca Romana Mancini & Roberto Marci & Giulia Bordi & Donate, 2014. "Exposure to Endocrine Disrupters and Nuclear Receptor Gene Expression in Infertile and Fertile Women from Different Italian Areas," IJERPH, MDPI, vol. 11(10), pages 1-19, September.
    • Handle: RePEc:gam:jijerp:v:11:y:2014:i:10:p:10146-10164:d:40785
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    Citations

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    Cited by:

    1. Yuan Meng & Ren Lin & Fengjuan Wu & Qi Sun & Lihong Jia, 2018. "Decreased Capacity for Sperm Production Induced by Perinatal Bisphenol A Exposure Is Associated with an Increased Inflammatory Response in the Offspring of C57BL/6 Male Mice," IJERPH, MDPI, vol. 15(10), pages 1-11, October.
    2. Cinzia La Rocca & Sabrina Tait & Cristiana Guerranti & Luca Busani & Francesca Ciardo & Bruno Bergamasco & Guido Perra & Francesca Romana Mancini & Roberto Marci & Giulia Bordi & Donatella Caserta & S, 2015. "Exposure to Endocrine Disruptors and Nuclear Receptors Gene Expression in Infertile and Fertile Men from Italian Areas with Different Environmental Features," IJERPH, MDPI, vol. 12(10), pages 1-20, October.

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