IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v11y2014i5p5208-5223d36073.html
   My bibliography  Save this article

Specific Association of Teratogen and Toxicant Metals in Hair of Newborns with Congenital Birth Defects or Developmentally Premature Birth in a Cohort of Couples with Documented Parental Exposure to Military Attacks: Observational Study at Al Shifa Hospital, Gaza, Palestine

Author

Listed:
  • Paola Manduca

    (Dept. Scienze della Terra, Ambientali e della Vita, University of Genoa, Genova 16132, Italy)

  • Awny Naim

    (Palestinina Energy and Natural Resources Authority, Gaza City, Palestine
    These authors contributed equally to this work.)

  • Simona Signoriello

    (Department of Medical Health and Preventive Medicine, Second University of Naples, Napoli 80100, Italy
    These authors contributed equally to this work.)

Abstract

This study was undertaken in Gaza, Palestine, in a cohort of babies born in 2011. Hair samples of newborns were analyzed for metal load by DRC-ICP-MS. We report specific level of contamination by teratogen/toxicants metals of newborn babies, environmentally unexposed, according to their phenotypes at birth: normal full term babies, birth defects or developmentally premature. The occurrence of birth defects was previously shown to be correlated in this cohort to documented exposure of parents to weapons containing metal contaminants, during attacks in 2009. We detect, in significantly higher amounts than in normal babies, different specific teratogen or toxicant elements, known weapons’ components, characteristic for each of birth defect or premature babies. This is the first attempt to our knowledge to directly link a phenotype at birth with the in utero presence of specific teratogen and/or toxicant metals in a cohort with known episodes of acute exposure of parents to environmental contamination by these same metals, in this case delivered by weaponry The babies were conceived 20–25 months after the major known parental exposure; the specific link of newborn phenotypes to war-remnant metal contaminants, suggests that mothers’ contamination persists in time, and that the exposure may have a long term effect.

Suggested Citation

  • Paola Manduca & Awny Naim & Simona Signoriello, 2014. "Specific Association of Teratogen and Toxicant Metals in Hair of Newborns with Congenital Birth Defects or Developmentally Premature Birth in a Cohort of Couples with Documented Parental Exposure to M," IJERPH, MDPI, vol. 11(5), pages 1-16, May.
    • Handle: RePEc:gam:jijerp:v:11:y:2014:i:5:p:5208-5223:d:36073
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/11/5/5208/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/11/5/5208/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Arturas Petronis, 2010. "Epigenetics as a unifying principle in the aetiology of complex traits and diseases," Nature, Nature, vol. 465(7299), pages 721-727, June.
    2. Awny Naim & Hedaya Al Dalies & Mohammed El Balawi & Eman Salem & Kholud Al Meziny & Raneem Al Shawwa & Roberto Minutolo & Paola Manduca, 2012. "Birth Defects in Gaza: Prevalence, Types, Familiarity and Correlation with Environmental Factors," IJERPH, MDPI, vol. 9(5), pages 1-16, May.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Paola Manduca & Nabil Al Baraquni & Stefano Parodi, 2020. "Long Term Risks to Neonatal Health from Exposure to War—9 Years Long Survey of Reproductive Health and Contamination by Weapon-Delivered Heavy Metals in Gaza, Palestine," IJERPH, MDPI, vol. 17(7), pages 1-20, April.
    2. Nabil al Baraquoni & Samir R. Qouta & Mervi Vänskä & Safwat Y. Diab & Raija-Leena Punamäki & Paola Manduca, 2020. "It Takes Time to Unravel the Ecology of War in Gaza, Palestine: Long-Term Changes in Maternal, Newborn and Toddlers’ Heavy Metal Loads, and Infant and Toddler Developmental Milestones in the Aftermath," IJERPH, MDPI, vol. 17(18), pages 1-18, September.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Douglas Almond & Janet Currie, 2011. "Killing Me Softly: The Fetal Origins Hypothesis," Journal of Economic Perspectives, American Economic Association, vol. 25(3), pages 153-172, Summer.
    2. Tafere, Kibrom, 2016. "Inter-generational Effects of Early Childhood Shocks on Human Capital: Evidence from Ethiopia," 2016 Annual Meeting, July 31-August 2, Boston, Massachusetts 236056, Agricultural and Applied Economics Association.
    3. Bhalotra, Sonia & Karlsson, Martin & Nilsson, Therese, 2014. "Life Expectancy and Mother-Baby Interventions. Evidence from A Historical Trial," Ruhr Economic Papers 504, RWI - Leibniz-Institut für Wirtschaftsforschung, Ruhr-University Bochum, TU Dortmund University, University of Duisburg-Essen.
    4. Janet Currie, 2011. "Ungleichheiten bei der Geburt: Einige Ursachen und Folgen," Perspektiven der Wirtschaftspolitik, Verein für Socialpolitik, vol. 12(s1), pages 42-65, May.
    5. Sonia Bhalotra & Martin Karlsson & Therese Nilsson, 2014. "Life Expectancy and Mother-Baby Interventions. Evidence from A Historical Trial," Ruhr Economic Papers 0504, Rheinisch-Westfälisches Institut für Wirtschaftsforschung, Ruhr-Universität Bochum, Universität Dortmund, Universität Duisburg-Essen.
    6. Janet Currie, 2011. "Inequality at Birth: Some Causes and Consequences," American Economic Review, American Economic Association, vol. 101(3), pages 1-22, May.
    7. Sherrie Lessans & Susan G. Dorsey, 2013. "The Role for Epigenetic Modifications in Pain and Analgesia Response," Nursing Research and Practice, Hindawi, vol. 2013, pages 1-6, October.
    8. Vincenzo Atella & Edoardo Di Porto & Joanna Kopinska, 2016. "Heterogenous mechanisms in WWII stress transmission: evidence from a natural experiment," CEIS Research Paper 385, Tor Vergata University, CEIS, revised 01 Aug 2017.
    9. Mauro Cristaldi & Cristiano Foschi & Germana Szpunar & Carlo Brini & Fiorenzo Marinelli & Lucio Triolo, 2013. "Toxic Emissions from a Military Test Site in the Territory of Sardinia, Italy," IJERPH, MDPI, vol. 10(4), pages 1-16, April.
    10. Daniel K Mroczek, 2020. "Personality and Healthy Aging in 1945 and 2020: Reflecting on 75 Years of Research and Theory," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 75(3), pages 471-473.
    11. repec:zbw:rwirep:0504 is not listed on IDEAS
    12. Paola Manduca & Nabil Al Baraquni & Stefano Parodi, 2020. "Long Term Risks to Neonatal Health from Exposure to War—9 Years Long Survey of Reproductive Health and Contamination by Weapon-Delivered Heavy Metals in Gaza, Palestine," IJERPH, MDPI, vol. 17(7), pages 1-20, April.
    13. Nabil al Baraquoni & Samir R. Qouta & Mervi Vänskä & Safwat Y. Diab & Raija-Leena Punamäki & Paola Manduca, 2020. "It Takes Time to Unravel the Ecology of War in Gaza, Palestine: Long-Term Changes in Maternal, Newborn and Toddlers’ Heavy Metal Loads, and Infant and Toddler Developmental Milestones in the Aftermath," IJERPH, MDPI, vol. 17(18), pages 1-18, September.
    14. Ray, Mukesh K. & Maredia, Mywish K., 2018. "Legume Technologies as a Sustainable Solution to Climatic Shocks: Evidence from Malawi," 2018 Annual Meeting, August 5-7, Washington, D.C. 273873, Agricultural and Applied Economics Association.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:11:y:2014:i:5:p:5208-5223:d:36073. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.