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Epigenetics as a unifying principle in the aetiology of complex traits and diseases

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  • Arturas Petronis

    (The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health)

Abstract

Epigenetic modifications of DNA and histones might be crucial for understanding the molecular basis of complex phenotypes. One reason for this is that epigenetic factors are sometimes malleable and plastic enough to react to cues from the external and internal environments. Such induced epigenetic changes can be solidified and propagated during cell division, resulting in permanent maintenance of the acquired phenotype. In addition, the finding that there is partial epigenetic stability in somatic and germline cells allows insight into the molecular mechanisms of heritability. Epigenetics can provide a new framework for the search of aetiological factors in complex traits and diseases.

Suggested Citation

  • Arturas Petronis, 2010. "Epigenetics as a unifying principle in the aetiology of complex traits and diseases," Nature, Nature, vol. 465(7299), pages 721-727, June.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7299:d:10.1038_nature09230
    DOI: 10.1038/nature09230
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    Cited by:

    1. Bhalotra, Sonia & Karlsson, Martin & Nilsson, Therese, 2014. "Life Expectancy and Mother-Baby Interventions. Evidence from A Historical Trial," Ruhr Economic Papers 504, RWI - Leibniz-Institut für Wirtschaftsforschung, Ruhr-University Bochum, TU Dortmund University, University of Duisburg-Essen.
    2. Janet Currie, 2011. "Inequality at Birth: Some Causes and Consequences," American Economic Review, American Economic Association, vol. 101(3), pages 1-22, May.
    3. Janet Currie, 2011. "Ungleichheiten bei der Geburt: Einige Ursachen und Folgen," Perspektiven der Wirtschaftspolitik, Verein für Socialpolitik, vol. 12(s1), pages 42-65, May.
    4. Sonia Bhalotra & Martin Karlsson & Therese Nilsson, 2014. "Life Expectancy and Mother-Baby Interventions. Evidence from A Historical Trial," Ruhr Economic Papers 0504, Rheinisch-Westfälisches Institut für Wirtschaftsforschung, Ruhr-Universität Bochum, Universität Dortmund, Universität Duisburg-Essen.
    5. Vincenzo Atella & Edoardo Di Porto & Joanna Kopinska, 2016. "Heterogenous mechanisms in WWII stress transmission: evidence from a natural experiment," CEIS Research Paper 385, Tor Vergata University, CEIS, revised 01 Aug 2017.
    6. Douglas Almond & Janet Currie, 2011. "Killing Me Softly: The Fetal Origins Hypothesis," Journal of Economic Perspectives, American Economic Association, vol. 25(3), pages 153-172, Summer.
    7. Sherrie Lessans & Susan G. Dorsey, 2013. "The Role for Epigenetic Modifications in Pain and Analgesia Response," Nursing Research and Practice, Hindawi, vol. 2013, pages 1-6, October.
    8. Paola Manduca & Awny Naim & Simona Signoriello, 2014. "Specific Association of Teratogen and Toxicant Metals in Hair of Newborns with Congenital Birth Defects or Developmentally Premature Birth in a Cohort of Couples with Documented Parental Exposure to M," IJERPH, MDPI, vol. 11(5), pages 1-16, May.
    9. Daniel K Mroczek, 2020. "Personality and Healthy Aging in 1945 and 2020: Reflecting on 75 Years of Research and Theory," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 75(3), pages 471-473.
    10. repec:zbw:rwirep:0504 is not listed on IDEAS
    11. Tafere, Kibrom, 2016. "Inter-generational Effects of Early Childhood Shocks on Human Capital: Evidence from Ethiopia," 2016 Annual Meeting, July 31-August 2, Boston, Massachusetts 236056, Agricultural and Applied Economics Association.
    12. Ray, Mukesh K. & Maredia, Mywish K., 2018. "Legume Technologies as a Sustainable Solution to Climatic Shocks: Evidence from Malawi," 2018 Annual Meeting, August 5-7, Washington, D.C. 273873, Agricultural and Applied Economics Association.

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