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Transmission–virulence trade-offs in vector-borne diseases

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  • Alizon, Samuel
  • van Baalen, Minus

Abstract

Though it is commonly supposed that there is a trade-off between virulence and transmission, there is little data and little insight into what it should look like. Here, we consider the specific case of vector-borne parasites (inspired by human malaria) and analyse an embedded model to understand how specific life-cycle aspects may affect this trade-off. First, we find that, for such parasites, the transmission function may have an S-shape. Second, we find that the trade-off obtained for vector-borne parasites is less sensitive to parameter variations than the trade-off obtained for directly transmitted parasites. Third, we find that other parasite traits, such as the conversion from replicative to infective stages, could have important epidemiological implications. Finally, we compare the effect of treatments targeting either the asexual or the sexual parasite life-stage.

Suggested Citation

  • Alizon, Samuel & van Baalen, Minus, 2008. "Transmission–virulence trade-offs in vector-borne diseases," Theoretical Population Biology, Elsevier, vol. 74(1), pages 6-15.
    • Handle: RePEc:eee:thpobi:v:74:y:2008:i:1:p:6-15
    DOI: 10.1016/j.tpb.2008.04.003
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    References listed on IDEAS

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    1. Sylvain Gandon & Margaret J. Mackinnon & Sean Nee & Andrew F. Read, 2001. "Imperfect vaccines and the evolution of pathogen virulence," Nature, Nature, vol. 414(6865), pages 751-756, December.
    2. Mario Recker & Sean Nee & Peter C. Bull & Sam Kinyanjui & Kevin Marsh & Chris Newbold & Sunetra Gupta, 2004. "Transient cross-reactive immune responses can orchestrate antigenic variation in malaria," Nature, Nature, vol. 429(6991), pages 555-558, June.
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    Cited by:

    1. Arenas, Abraham J. & González-Parra, Gilberto & Villanueva Micó, Rafael-J., 2010. "Modeling toxoplasmosis spread in cat populations under vaccination," Theoretical Population Biology, Elsevier, vol. 77(4), pages 227-237.
    2. Kathryn A. Hanley & Hélène Cecilia & Sasha R. Azar & Brett A. Moehn & Jordan T. Gass & Natalia I. Oliveira da Silva & Wanqin Yu & Ruimei Yun & Benjamin M. Althouse & Nikos Vasilakis & Shannan L. Rossi, 2024. "Trade-offs shaping transmission of sylvatic dengue and Zika viruses in monkey hosts," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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