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An optimal response-adaptive design with dual constraints

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  • Biswas, Atanu
  • Bhattacharya, Rahul

Abstract

The article deals with an optimal response-adaptive design for allocating patients among two competing treatments in a phase III clinical trial. An optimal response-adaptive target is developed for a general class of response distributions subject to two clinically relevant constraints. Various theoretical and numerical properties of the proposed procedure are investigated and compared with some existing competitors. A data study is also included for the assessment of the proposed procedure in real situation.

Suggested Citation

  • Biswas, Atanu & Bhattacharya, Rahul, 2010. "An optimal response-adaptive design with dual constraints," Statistics & Probability Letters, Elsevier, vol. 80(3-4), pages 177-185, February.
    • Handle: RePEc:eee:stapro:v:80:y:2010:i:3-4:p:177-185
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    References listed on IDEAS

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    1. Lanju Zhang & William F. Rosenberger, 2006. "Response-Adaptive Randomization for Clinical Trials with Continuous Outcomes," Biometrics, The International Biometric Society, vol. 62(2), pages 562-569, June.
    2. William F. Rosenberger & Nigel Stallard & Anastasia Ivanova & Cherice N. Harper & Michelle L. Ricks, 2001. "Optimal Adaptive Designs for Binary Response Trials," Biometrics, The International Biometric Society, vol. 57(3), pages 909-913, September.
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    1. Biswas, Atanu & Bhattacharya, Rahul, 2011. "Optimal response-adaptive allocation designs in phase III clinical trials: Incorporating ethics in optimality," Statistics & Probability Letters, Elsevier, vol. 81(8), pages 1155-1160, August.

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