IDEAS home Printed from https://ideas.repec.org/a/eee/respol/v48y2019i5p1113-1127.html
   My bibliography  Save this article

Moving from non-interventionism to industrial strategy: The roles of tentative and definitive governance in support of the UK biotech sector

Author

Listed:
  • Hopkins, Michael M.
  • Crane, Philippa
  • Nightingale, Paul
  • Baden-Fuller, Charles

Abstract

This paper develops a framework for characterising tentative and definitive governance modes. Using investor financing of UK-based therapeutic biotech firms as a context, the paper traces how policy makers have blended tentative and definitive elements in the design and implementation of six different kinds of policies to spur investor support for these firms. We find that tentative and definitive governance are used together to balance the need for certainty with necessary responsiveness to the dynamic circumstances that surround technological emergence. Moreover we show that the relative use of tentative and definitive modes is shaped as much by higher landscape-level influences as by technology or sector-level factors. Challenges are also identified, for instance, how to maintain synergistic rather than either/or relationships between state and non-state actors when both hesitate to engage with markets at different times.

Suggested Citation

  • Hopkins, Michael M. & Crane, Philippa & Nightingale, Paul & Baden-Fuller, Charles, 2019. "Moving from non-interventionism to industrial strategy: The roles of tentative and definitive governance in support of the UK biotech sector," Research Policy, Elsevier, vol. 48(5), pages 1113-1127.
    • Handle: RePEc:eee:respol:v:48:y:2019:i:5:p:1113-1127
    DOI: 10.1016/j.respol.2019.01.008
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0048733319300162
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.respol.2019.01.008?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Lazonick,William, 1993. "Business Organization and the Myth of the Market Economy," Cambridge Books, Cambridge University Press, number 9780521447881, November.
    2. Bronwyn Hall, 2004. "The financing of research and development," Chapters, in: Anthony Bartzokas & Sunil Mani (ed.), Financial Systems, Corporate Investment in Innovation, and Venture Capital, chapter 2, Edward Elgar Publishing.
    3. Salter, Ammon J. & Martin, Ben R., 2001. "The economic benefits of publicly funded basic research: a critical review," Research Policy, Elsevier, vol. 30(3), pages 509-532, March.
    4. Rotolo, Daniele & Hicks, Diana & Martin, Ben R., 2015. "What is an emerging technology?," Research Policy, Elsevier, vol. 44(10), pages 1827-1843.
    5. Michael M. Hopkins & Philippa A. Crane & Paul Nightingale & Charles Baden-Fuller, 2013. "Buying big into biotech: scale, financing, and the industrial dynamics of UK biotech, 1980--2009," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 22(4), pages 903-952, August.
    6. Arthur, W Brian, 1989. "Competing Technologies, Increasing Returns, and Lock-In by Historical Events," Economic Journal, Royal Economic Society, vol. 99(394), pages 116-131, March.
    7. Owen, Geoffrey & Hopkins, Michael M., 2016. "Science, the State and the City: Britain's Struggle to Succeed in Biotechnology," OUP Catalogue, Oxford University Press, number 9780198728009.
    8. Jacqueline Senker, 2004. "Trends and gaps in biotechnology policies in European Member States since 1994," Science and Public Policy, Oxford University Press, vol. 31(5), pages 385-395, October.
    9. Hopkins, Michael M. & Nightingale, Paul, 2006. "Strategic risk management using complementary assets: Organizational capabilities and the commercialization of human genetic testing in the UK," Research Policy, Elsevier, vol. 35(3), pages 355-374, April.
    10. Philip Scranton, 2006. "Technology, science and American innovation," Business History, Taylor & Francis Journals, vol. 48(3), pages 311-331.
    11. Luigi Orsenigo, 2016. "Industrial Policies for Biotechnology: Limits and New Perspectives," Politica economica, Società editrice il Mulino, issue 2, pages 253-296.
    12. Paul Westhead & David Storey, 1997. "Financial constraints on the growth of high technology small firms in the United Kingdom," Applied Financial Economics, Taylor & Francis Journals, vol. 7(2), pages 197-201.
    13. Reinhart, Carmen & Kirkegaard, Jacob & Sbrancia, Belen, 2011. "Financial repression redux," MPRA Paper 31641, University Library of Munich, Germany.
    14. Valérie Revest & Sandro Sapio, 2008. "Financing Technology-Based Small Firms in Europe: a review of the empirical evidence," LEM Papers Series 2008/23, Laboratory of Economics and Management (LEM), Sant'Anna School of Advanced Studies, Pisa, Italy.
    15. Ramjerdi, Farideh & Fearnley, Nils, 2014. "Risk and irreversibility of transport interventions," Transportation Research Part A: Policy and Practice, Elsevier, vol. 60(C), pages 31-39.
    16. Nathan ROSENBERG, 2009. "Why do firms do basic research (with their own money)?," World Scientific Book Chapters, in: Nathan Rosenberg (ed.), Studies On Science And The Innovation Process Selected Works of Nathan Rosenberg, chapter 11, pages 225-234, World Scientific Publishing Co. Pte. Ltd..
    17. Rogge, Karoline S. & Reichardt, Kristin, 2016. "Policy mixes for sustainability transitions: An extended concept and framework for analysis," Research Policy, Elsevier, vol. 45(8), pages 1620-1635.
    18. Chris Freeman & Luc Soete, 1997. "The Economics of Industrial Innovation, 3rd Edition," MIT Press Books, The MIT Press, edition 3, volume 1, number 0262061953, December.
    19. Kuhlmann, Stefan & Stegmaier, Peter & Konrad, Kornelia, 2019. "The tentative governance of emerging science and technology—A conceptual introduction," Research Policy, Elsevier, vol. 48(5), pages 1091-1097.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Kuhlmann, Stefan & Stegmaier, Peter & Konrad, Kornelia, 2019. "The tentative governance of emerging science and technology—A conceptual introduction," Research Policy, Elsevier, vol. 48(5), pages 1091-1097.
    2. Gilding, Michael & Brennecke, Julia & Bunton, Vikki & Lusher, Dean & Molloy, Peter L. & Codoreanu, Alex, 2020. "Network failure: Biotechnology firms, clusters and collaborations far from the world superclusters," Research Policy, Elsevier, vol. 49(2).
    3. Josie Coburn & Frederique Bone & Andy C. Stirling & Michael M. Hopkins & Jorge Mestre-Ferrandiz & Stathis Arapostathis & Martin J. Llewelyn, 2021. "Appraising research policy instrument mixes: a multicriteria mapping study in six European countries of diagnostic innovation to manage antimicrobial resistance," SPRU Working Paper Series 2021-03, SPRU - Science Policy Research Unit, University of Sussex Business School.
    4. Coburn, Josie & Bone, Frederique & Hopkins, Michael M. & Stirling, Andy & Mestre-Ferrandiz, Jorge & Arapostathis, Stathis & Llewelyn, Martin J., 2021. "Appraising research policy instrument mixes: a multicriteria mapping study in six European countries of diagnostic innovation to manage antimicrobial resistance," Research Policy, Elsevier, vol. 50(4).
    5. Child, John & Narooz, Rose & Hsieh, Linda & Elbanna, Said & Karmowska, Joanna & Marinova, Svetla & Puthusserry, Pushyarag & Tsai, Terence & Zhang, Yunlu, 2022. "External resource provision and the international performance of SMEs – A contextual analysis," Journal of International Management, Elsevier, vol. 28(3).
    6. Borrás, Susana & Edler, Jakob, 2020. "The roles of the state in the governance of socio-technical systems’ transformation," Research Policy, Elsevier, vol. 49(5).
    7. Danli Du & Xiaojie Jian, 2024. "Enhancing the resilience of regional digital innovation ecosystems: a pathway analysis from the lens of resource orchestration theory," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 73(4), pages 1811-1838, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Stoneman, Paul, 2011. "Soft Innovation: Economics, Product Aesthetics, and the Creative Industries," OUP Catalogue, Oxford University Press, number 9780199697021.
    2. Kapoor, Rahul & Klueter, Thomas, 2020. "Progress and setbacks: The two faces of technology emergence," Research Policy, Elsevier, vol. 49(1).
    3. Petersen, Alexander M. & Rotolo, Daniele & Leydesdorff, Loet, 2016. "A triple helix model of medical innovation: Supply, demand, and technological capabilities in terms of Medical Subject Headings," Research Policy, Elsevier, vol. 45(3), pages 666-681.
    4. Archibugi, Daniele & Filippetti, Andrea, 2018. "The retreat of public research and its adverse consequences on innovation," Technological Forecasting and Social Change, Elsevier, vol. 127(C), pages 97-111.
    5. Mazzucato, Mariana & Semieniuk, Gregor, 2018. "Financing renewable energy: Who is financing what and why it matters," Technological Forecasting and Social Change, Elsevier, vol. 127(C), pages 8-22.
    6. Yoruk, Esin & Radosevic, Slavo & Fischer, Bruno, 2023. "Technological profiles, upgrading and the dynamics of growth: Country-level patterns and trajectories across distinct stages of development," Research Policy, Elsevier, vol. 52(8).
    7. Alex Coad & Agustí Segarra-Blasco & Mercedes Teruel, 2021. "A bit of basic, a bit of applied? R&D strategies and firm performance," The Journal of Technology Transfer, Springer, vol. 46(6), pages 1758-1783, December.
    8. Elias Carayannis & Marco Vinzenzi & John Draper & Nikos Kanellos, 2024. "Can Fusion Be the Next General-Purpose Technology? Theory, Policy, Practice, and Politics Perspectives on Stewarding Fusion Energy Research," Journal of the Knowledge Economy, Springer;Portland International Center for Management of Engineering and Technology (PICMET), vol. 15(2), pages 9497-9514, June.
    9. Cohen, Wesley M., 2010. "Fifty Years of Empirical Studies of Innovative Activity and Performance," Handbook of the Economics of Innovation, in: Bronwyn H. Hall & Nathan Rosenberg (ed.), Handbook of the Economics of Innovation, edition 1, volume 1, chapter 0, pages 129-213, Elsevier.
    10. Cowling, Marc & Ughetto, Elisa & Lee, Neil, 2018. "The innovation debt penalty: Cost of debt, loan default, and the effects of a public loan guarantee on high-tech firms," Technological Forecasting and Social Change, Elsevier, vol. 127(C), pages 166-176.
    11. Seokbeom Kwon & Jan Youtie & Alan Porter & Nils Newman, 2024. "How does regulatory uncertainty shape the innovation process? Evidence from the case of nanomedicine," The Journal of Technology Transfer, Springer, vol. 49(1), pages 262-302, February.
    12. Mark Knell & Simone Vannuccini, 2022. "Tools and concepts for understanding disruptive technological change after Schumpeter," Jena Economics Research Papers 2022-005, Friedrich-Schiller-University Jena.
    13. Stavins, Robert & Jaffe, Adam & Newell, Richard, 2000. "Technological Change and the Environment," Working Paper Series rwp00-002, Harvard University, John F. Kennedy School of Government.
    14. Hoppmann, Joern, 2021. "Hand in hand to Nowhereland? How the resource dependence of research institutes influences their co-evolution with industry," Research Policy, Elsevier, vol. 50(2).
    15. Mueller, Elisabeth & Zimmermann, Volker, 2006. "The Importance of Equity Finance for R&D Activity: Are There Differences Between Young and OldCompanies?," ZEW Discussion Papers 06-014, ZEW - Leibniz Centre for European Economic Research.
    16. Befort, N., 2020. "Going beyond definitions to understand tensions within the bioeconomy: The contribution of sociotechnical regimes to contested fields," Technological Forecasting and Social Change, Elsevier, vol. 153(C).
    17. Christian Rammer & Dirk Czarnitzki & Alfred Spielkamp, 2009. "Innovation success of non-R&D-performers: substituting technology by management in SMEs," Small Business Economics, Springer, vol. 33(1), pages 35-58, June.
    18. Inga Ulnicane & William Knight & Tonii Leach & Bernd Carsten Stahl & Winter-Gladys Wanjiku, 2021. "Framing governance for a contested emerging technology:insights from AI policy [The next space race is Artificial Intelligence]," Policy and Society, Darryl S. Jarvis and M. Ramesh, vol. 40(2), pages 158-177.
    19. Pitelis, Alkis & Vasilakos, Nicholas & Chalvatzis, Konstantinos, 2020. "Fostering innovation in renewable energy technologies: Choice of policy instruments and effectiveness," Renewable Energy, Elsevier, vol. 151(C), pages 1163-1172.
    20. Christian Pierdzioch & Andrea Schertler, 2007. "Sources of Predictability of European Stock Markets for High-technology Firms," The European Journal of Finance, Taylor & Francis Journals, vol. 13(1), pages 1-27.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:respol:v:48:y:2019:i:5:p:1113-1127. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.elsevier.com/locate/respol .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.