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Modeling cancer immunotherapy: Assessing the effects of lymphocytes on cancer cell growth and motility

Author

Listed:
  • Ramos, R.A.
  • Zapata, Jair
  • Condat, C.A.
  • Deisboeck, Thomas S.

Abstract

A mesoscopic model is used to describe the effects of lymphocyte activity on a growing tumor. The model yields novel insights into the tumor–immune system interaction. In particular, we found that the presence of a putative chemotactic messenger that helps guide the lymphocytes towards the tumor is not critical to elicit the anti-tumor effects of the immune system, while lymphocytes that block tumor cell migration contribute to limit cancer expansion and thus have a more significant therapeutic impact.

Suggested Citation

  • Ramos, R.A. & Zapata, Jair & Condat, C.A. & Deisboeck, Thomas S., 2013. "Modeling cancer immunotherapy: Assessing the effects of lymphocytes on cancer cell growth and motility," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 392(10), pages 2415-2425.
    • Handle: RePEc:eee:phsmap:v:392:y:2013:i:10:p:2415-2425
    DOI: 10.1016/j.physa.2013.01.047
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    References listed on IDEAS

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    1. Piccoli, B. & Castiglione, F., 2006. "Optimal vaccine scheduling in cancer immunotherapy," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 370(2), pages 672-680.
    2. Ben D. MacArthur & Richard O. C. Oreffo, 2005. "Bridging the gap," Nature, Nature, vol. 433(7021), pages 19-19, January.
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