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ncRNA-mediated bistability in the synthesis of hundreds of distinct mRNAs and proteins

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  • Zhdanov, Vladimir P.

Abstract

The kinetics of gene expression can be bistable due to the feedback between the mRNA and protein formation. In eukaryotic cells, the interplay between mRNAs and proteins can be influenced by non-coding RNAs. Some of these RNAs, e.g., microRNAs, may target hundreds of distinct mRNAs. The model presented here shows how a non-coding RNA can be used as a mediator in order to involve numerous mRNAs and proteins into a bistable network.

Suggested Citation

  • Zhdanov, Vladimir P., 2010. "ncRNA-mediated bistability in the synthesis of hundreds of distinct mRNAs and proteins," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 389(4), pages 887-890.
    • Handle: RePEc:eee:phsmap:v:389:y:2010:i:4:p:887-890
    DOI: 10.1016/j.physa.2009.11.028
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    References listed on IDEAS

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    1. Matthias Selbach & Björn Schwanhäusser & Nadine Thierfelder & Zhuo Fang & Raya Khanin & Nikolaus Rajewsky, 2008. "Widespread changes in protein synthesis induced by microRNAs," Nature, Nature, vol. 455(7209), pages 58-63, September.
    2. Daehyun Baek & Judit Villén & Chanseok Shin & Fernando D. Camargo & Steven P. Gygi & David P. Bartel, 2008. "The impact of microRNAs on protein output," Nature, Nature, vol. 455(7209), pages 64-71, September.
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