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Toxicokinetic–toxicodynamic modelling in an individual based context—Consequences of parameter variability

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  • Ashauer, Roman

Abstract

Toxicokinetic–toxicodynamic (TKTD) models simulate the time-course of toxicant concentration in the organism and toxicity at the level of the organism. A link between TKTD models that simulate survival and individual based models for populations (IBMs) is proposed which allows TKTD parameters to vary between individuals. The TKTD-IBM predicts different survival in response to toxicants when TKTD parameters vary amongst individuals compared to the survival predicted with fixed TKTD parameters. The model with fixed parameters represents the concept of stochastic death whereas the model with variable parameters behaves, at least partly, according to the individual tolerance distribution concept. The whole set of TKTD parameters of an individual can be interpreted as constituting “individual tolerance”.

Suggested Citation

  • Ashauer, Roman, 2010. "Toxicokinetic–toxicodynamic modelling in an individual based context—Consequences of parameter variability," Ecological Modelling, Elsevier, vol. 221(9), pages 1325-1328.
    • Handle: RePEc:eee:ecomod:v:221:y:2010:i:9:p:1325-1328
    DOI: 10.1016/j.ecolmodel.2010.01.015
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    References listed on IDEAS

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    1. Wang, Magnus & Grimm, Volker, 2007. "Home range dynamics and population regulation: An individual-based model of the common shrew Sorex araneus," Ecological Modelling, Elsevier, vol. 205(3), pages 397-409.
    2. Baas, J. & Jager, T. & Kooijman, S.A.L.M., 2009. "Estimation of no effect concentrations from exposure experiments when values scatter among individuals," Ecological Modelling, Elsevier, vol. 220(3), pages 411-418.
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    Cited by:

    1. Schmitt, Walter & Bruns, Eric & Dollinger, Margit & Sowig, Peter, 2013. "Mechanistic TK/TD-model simulating the effect of growth inhibitors on Lemna populations," Ecological Modelling, Elsevier, vol. 255(C), pages 1-10.
    2. Liu, Chun & Bednarska, Agnieszka J. & Sibly, Richard M. & Murfitt, Roger C. & Edwards, Peter & Thorbek, Pernille, 2014. "Incorporating toxicokinetics into an individual-based model for more realistic pesticide exposure estimates: A case study of the wood mouse," Ecological Modelling, Elsevier, vol. 280(C), pages 30-39.

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