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A nonparametric approach to weighted estimating equations for regression analysis with missing covariates

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  • Creemers, An
  • Aerts, Marc
  • Hens, Niel
  • Molenberghs, Geert

Abstract

Missing data often occur in regression analysis. Imputation, weighting, direct likelihood, and Bayesian inference are typical approaches for missing data analysis. The focus is on missing covariate data, a common complication in the analysis of sample surveys and clinical trials. A key quantity when applying weighted estimators is the mean score contribution of observations with missing covariate(s), conditional on the observed covariates. This mean score can be estimated parametrically or nonparametrically by its empirical average using the complete case data in case of repeated values of the observed covariates, typically assuming categorical or categorized covariates. A nonparametric kernel based estimator is proposed for this mean score, allowing the full exploitation of the continuous nature of the covariates. The performance of the kernel based method is compared to that of a complete case analysis, inverse probability weighting, doubly robust estimators and multiple imputation, through simulations.

Suggested Citation

  • Creemers, An & Aerts, Marc & Hens, Niel & Molenberghs, Geert, 2012. "A nonparametric approach to weighted estimating equations for regression analysis with missing covariates," Computational Statistics & Data Analysis, Elsevier, vol. 56(1), pages 100-113, January.
    • Handle: RePEc:eee:csdana:v:56:y:2012:i:1:p:100-113
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    References listed on IDEAS

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    1. Hardle, Wolfgang & Linton, Oliver, 1986. "Applied nonparametric methods," Handbook of Econometrics, in: R. F. Engle & D. McFadden (ed.), Handbook of Econometrics, edition 1, volume 4, chapter 38, pages 2295-2339, Elsevier.
    2. James R. Carpenter & Michael G. Kenward & Stijn Vansteelandt, 2006. "A comparison of multiple imputation and doubly robust estimation for analyses with missing data," Journal of the Royal Statistical Society Series A, Royal Statistical Society, vol. 169(3), pages 571-584, July.
    3. Wang, Suojin & Wang, C. Y., 2001. "A note on kernel assisted estimators in missing covariate regression," Statistics & Probability Letters, Elsevier, vol. 55(4), pages 439-449, December.
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    Cited by:

    1. Shen-Ming Lee & T. Martin Lukusa & Chin-Shang Li, 2020. "Estimation of a zero-inflated Poisson regression model with missing covariates via nonparametric multiple imputation methods," Computational Statistics, Springer, vol. 35(2), pages 725-754, June.
    2. T. Martin Lukusa & Shen-Ming Lee & Chin-Shang Li, 2016. "Semiparametric estimation of a zero-inflated Poisson regression model with missing covariates," Metrika: International Journal for Theoretical and Applied Statistics, Springer, vol. 79(4), pages 457-483, May.
    3. Daniel, Rhian M. & Kenward, Michael G., 2012. "A method for increasing the robustness of multiple imputation," Computational Statistics & Data Analysis, Elsevier, vol. 56(6), pages 1624-1643.

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