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Jackstraw inference for AJIVE data integration

Author

Listed:
  • Yang, Xi
  • Hoadley, Katherine A.
  • Hannig, Jan
  • Marron, J.S.

Abstract

In the age of big data, data integration is a critical step especially in the understanding of how diverse data types work together and work separately. Among data integration methods, the Angle-Based Joint and Individual Variation Explained (AJIVE) approach is particularly attractive because it not only studies joint behavior but also individual behavior. Typically AJIVE scores indicate important relationships between data objects, such as clusters. An important challenge is understanding which features, i.e. variables, are associated with those relationships. This challenge is addressed by the proposal of a hypothesis test for assessing statistical significance of features. The new test is inspired by the related jackstraw method developed for Principal Component Analysis. We use a high-dimensional multi-genomic cancer data set as our strong motivation and deep illustration of the methodology.

Suggested Citation

  • Yang, Xi & Hoadley, Katherine A. & Hannig, Jan & Marron, J.S., 2023. "Jackstraw inference for AJIVE data integration," Computational Statistics & Data Analysis, Elsevier, vol. 180(C).
    • Handle: RePEc:eee:csdana:v:180:y:2023:i:c:s0167947322002298
    DOI: 10.1016/j.csda.2022.107649
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    References listed on IDEAS

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    1. Charles M. Perou & Therese Sørlie & Michael B. Eisen & Matt van de Rijn & Stefanie S. Jeffrey & Christian A. Rees & Jonathan R. Pollack & Douglas T. Ross & Hilde Johnsen & Lars A. Akslen & Øystein Flu, 2000. "Molecular portraits of human breast tumours," Nature, Nature, vol. 406(6797), pages 747-752, August.
    2. Feng, Qing & Jiang, Meilei & Hannig, Jan & Marron, J.S., 2018. "Angle-based joint and individual variation explained," Journal of Multivariate Analysis, Elsevier, vol. 166(C), pages 241-265.
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