IDEAS home Printed from https://ideas.repec.org/a/bpj/ijbist/v4y2008i1n4.html
   My bibliography  Save this article

Extended Instrumental Variables Estimation for Overall Effects

Author

Listed:
  • Joffe Marshall M

    (University of Pennsylvania)

  • Small Dylan

    (University of Pennsylvania)

  • Ten Have Thomas

    (University of Pennsylvania)

  • Brunelli Steve

    (University of Pennsylvania)

  • Feldman Harold I

    (University of Pennsylvania)

Abstract

We consider a method for extending instrumental variables methods in order to estimate the overall effect of a treatment or exposure. The approach is designed for settings in which the instrument influences both the treatment of interest and a secondary treatment also influenced by the primary treatment. We demonstrate that, while instrumental variables methods may be used to estimate the joint effects of the primary and secondary treatments, they cannot by themselves be used to estimate the overall effect of the primary treatment. However, instrumental variables methods may be used in conjunction with approaches for estimating the effect of the primary on the secondary treatment to estimate the overall effect of the primary treatment. We consider extending the proposed methods to deal with confounding of the effect of the instrument, mediation of the effect of the instrument by other variables, failure-time outcomes, and time-varying secondary treatments. We motivate our discussion by considering estimation of the overall effect of the type of vascular access among hemodialysis patients.

Suggested Citation

  • Joffe Marshall M & Small Dylan & Ten Have Thomas & Brunelli Steve & Feldman Harold I, 2008. "Extended Instrumental Variables Estimation for Overall Effects," The International Journal of Biostatistics, De Gruyter, vol. 4(1), pages 1-20, April.
    • Handle: RePEc:bpj:ijbist:v:4:y:2008:i:1:n:4
    DOI: 10.2202/1557-4679.1082
    as

    Download full text from publisher

    File URL: https://doi.org/10.2202/1557-4679.1082
    Download Restriction: For access to full text, subscription to the journal or payment for the individual article is required.
    File URL: https://libkey.io/10.2202/1557-4679.1082?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. James Robins & Andrea Rotnitzky, 2004. "Estimation of treatment effects in randomised trials with non-compliance and a dichotomous outcome using structural mean models," Biometrika, Biometrika Trust, vol. 91(4), pages 763-783, December.
    2. Thomas R. Ten Have & Marshall M. Joffe & Kevin G. Lynch & Gregory K. Brown & Stephen A. Maisto & Aaron T. Beck, 2007. "Causal Mediation Analyses with Rank Preserving Models," Biometrics, The International Biometric Society, vol. 63(3), pages 926-934, September.
    3. K. Newey, Whitney, 1985. "Generalized method of moments specification testing," Journal of Econometrics, Elsevier, vol. 29(3), pages 229-256, September.
    4. Ten Have, Thomas R. & Elliott, Michael R. & Joffe, Marshall & Zanutto, Elaine & Datto, Catherine, 2004. "Causal Models for Randomized Physician Encouragement Trials in Treating Primary Care Depression," Journal of the American Statistical Association, American Statistical Association, vol. 99, pages 16-25, January.
    5. Small, Dylan S., 2007. "Sensitivity Analysis for Instrumental Variables Regression With Overidentifying Restrictions," Journal of the American Statistical Association, American Statistical Association, vol. 102, pages 1049-1058, September.
    6. McClellan, Mark & Newhouse, Joseph P., 1997. "The marginal cost-effectiveness of medical technology: A panel instrumental-variables approach," Journal of Econometrics, Elsevier, vol. 77(1), pages 39-64, March.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Karim Chalak & Halbert White, 2011. "Viewpoint: An extended class of instrumental variables for the estimation of causal effects," Canadian Journal of Economics/Revue canadienne d'économique, John Wiley & Sons, vol. 44(1), pages 1-51, February.
    2. Markus Frölich & Martin Huber, 2017. "Direct and indirect treatment effects–causal chains and mediation analysis with instrumental variables," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 79(5), pages 1645-1666, November.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Doko Tchatoka, Firmin Sabro, 2012. "Specification Tests with Weak and Invalid Instruments," MPRA Paper 40185, University Library of Munich, Germany.
    2. Timothy B. Armstrong & Michal Kolesár, 2021. "Sensitivity analysis using approximate moment condition models," Quantitative Economics, Econometric Society, vol. 12(1), pages 77-108, January.
    3. Imbens, Guido W., 2014. "Instrumental Variables: An Econometrician's Perspective," IZA Discussion Papers 8048, Institute of Labor Economics (IZA).
    4. Gowrisankaran, Gautam & Town, Robert J., 1999. "Estimating the quality of care in hospitals using instrumental variables," Journal of Health Economics, Elsevier, vol. 18(6), pages 747-767, December.
    5. Guggenberger, Patrik, 2012. "A note on the (in)consistency of the test of overidentifying restrictions and the concepts of true and pseudo-true parameters," Economics Letters, Elsevier, vol. 117(3), pages 901-904.
    6. Stephens Alisa & Joffe Marshall & Keele Luke, 2016. "Generalized Structural Mean Models for Evaluating Depression as a Post-treatment Effect Modifier of a Jobs Training Intervention," Journal of Causal Inference, De Gruyter, vol. 4(2), pages 1, September.
    7. Paul Clarke & Frank Windmeijer, 2009. "Identification of Causal Effects on Binary Outcomes Using Structural Mean Models," The Centre for Market and Public Organisation 09/217, The Centre for Market and Public Organisation, University of Bristol, UK.
    8. Jing Huang & Ying Yuan & David Wetter, 2019. "Latent Class Dynamic Mediation Model with Application to Smoking Cessation Data," Psychometrika, Springer;The Psychometric Society, vol. 84(1), pages 1-18, March.
    9. Matthew A. Masten & Alexandre Poirier, 2021. "Salvaging Falsified Instrumental Variable Models," Econometrica, Econometric Society, vol. 89(3), pages 1449-1469, May.
    10. Ali Reza Soltanian & Soghrat Faghihzadeh, 2012. "A generalization of the Grizzle model to the estimation of treatment effects in crossover trials with non-compliance," Journal of Applied Statistics, Taylor & Francis Journals, vol. 39(5), pages 1037-1048, October.
    11. Barrow, Lisa & Rouse, Cecilia Elena, 2004. "Using market valuation to assess public school spending," Journal of Public Economics, Elsevier, vol. 88(9-10), pages 1747-1769, August.
    12. Li, Yuming, 1998. "Expected stock returns, risk premiums and volatilities of economic factors1," Journal of Empirical Finance, Elsevier, vol. 5(2), pages 69-97, June.
    13. Mariacristina De Nardi & Eric French & John Bailey Jones, 2016. "Medicaid Insurance in Old Age," American Economic Review, American Economic Association, vol. 106(11), pages 3480-3520, November.
    14. Han, Sukjin, 2021. "Identification in nonparametric models for dynamic treatment effects," Journal of Econometrics, Elsevier, vol. 225(2), pages 132-147.
    15. Moscone, Francesco & Siciliani, Luigi & Tosetti, Elisa & Vittadini, Giorgio, 2020. "Do public and private hospitals differ in quality? Evidence from Italy," Regional Science and Urban Economics, Elsevier, vol. 83(C).
    16. Richard Blundell & Jack Britton & Monica Costa Dias & Eric French, 2023. "The Impact of Health on Labor Supply near Retirement," Journal of Human Resources, University of Wisconsin Press, vol. 58(1), pages 282-334.
    17. David Figlio & Jens Ludwig, 2012. "Sex, Drugs, and Catholic Schools: Private Schooling and Non-Market Adolescent Behaviors," German Economic Review, Verein für Socialpolitik, vol. 13(4), pages 385-415, November.
    18. RUGE-MURCIA, Francisco J., 2010. "Estimating Nonlinear DSGE Models by the Simulated Method of Moments," Cahiers de recherche 2010-10, Universite de Montreal, Departement de sciences economiques.
    19. Imbens, Guido W & Angrist, Joshua D, 1994. "Identification and Estimation of Local Average Treatment Effects," Econometrica, Econometric Society, vol. 62(2), pages 467-475, March.
    20. Xu Cheng & Winston Wei Dou & Zhipeng Liao, 2022. "Macro‐Finance Decoupling: Robust Evaluations of Macro Asset Pricing Models," Econometrica, Econometric Society, vol. 90(2), pages 685-713, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:bpj:ijbist:v:4:y:2008:i:1:n:4. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Peter Golla (email available below). General contact details of provider: https://www.degruyter.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.