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False discovery control in large-scale spatial multiple testing

Author

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  • Wenguang Sun
  • Brian J. Reich
  • T. Tony Cai
  • Michele Guindani
  • Armin Schwartzman

Abstract

type="main" xml:id="rssb12064-abs-0001"> The paper develops a unified theoretical and computational framework for false discovery control in multiple testing of spatial signals. We consider both pointwise and clusterwise spatial analyses, and derive oracle procedures which optimally control the false discovery rate, false discovery exceedance and false cluster rate. A data-driven finite approximation strategy is developed to mimic the oracle procedures on a continuous spatial domain. Our multiple-testing procedures are asymptotically valid and can be effectively implemented using Bayesian computational algorithms for analysis of large spatial data sets. Numerical results show that the procedures proposed lead to more accurate error control and better power performance than conventional methods. We demonstrate our methods for analysing the time trends in tropospheric ozone in eastern USA.

Suggested Citation

  • Wenguang Sun & Brian J. Reich & T. Tony Cai & Michele Guindani & Armin Schwartzman, 2015. "False discovery control in large-scale spatial multiple testing," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 77(1), pages 59-83, January.
    • Handle: RePEc:bla:jorssb:v:77:y:2015:i:1:p:59-83
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    File URL: http://hdl.handle.net/10.1111/rssb.2014.77.issue-1
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    Citations

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    Cited by:

    1. Niels Lundtorp Olsen & Alessia Pini & Simone Vantini, 2021. "False discovery rate for functional data," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 30(3), pages 784-809, September.
    2. Yin Xia, 2017. "Testing and support recovery of multiple high-dimensional covariance matrices with false discovery rate control," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 26(4), pages 782-801, December.
    3. Wang, Jiangzhou & Cui, Tingting & Zhu, Wensheng & Wang, Pengfei, 2023. "Covariate-modulated large-scale multiple testing under dependence," Computational Statistics & Data Analysis, Elsevier, vol. 180(C).
    4. Brian J. Reich & Joseph Guinness & Simon N. Vandekar & Russell T. Shinohara & Ana†Maria Staicu, 2018. "Fully Bayesian spectral methods for imaging data," Biometrics, The International Biometric Society, vol. 74(2), pages 645-652, June.
    5. Wang, Xia & Shojaie, Ali & Zou, Jian, 2019. "Bayesian hidden Markov models for dependent large-scale multiple testing," Computational Statistics & Data Analysis, Elsevier, vol. 136(C), pages 123-136.
    6. Hassanniakalager, Arman & Baker, Paul L. & Platanakis, Emmanouil, 2024. "A False Discovery Rate approach to optimal volatility forecasting model selection," International Journal of Forecasting, Elsevier, vol. 40(3), pages 881-902.
    7. Laura D'Angelo & Antonio Canale & Zhaoxia Yu & Michele Guindani, 2023. "Bayesian nonparametric analysis for the detection of spikes in noisy calcium imaging data," Biometrics, The International Biometric Society, vol. 79(2), pages 1370-1382, June.
    8. Michele Guindani & Wesley O. Johnson, 2018. "More nonparametric Bayesian inference in applications," Statistical Methods & Applications, Springer;Società Italiana di Statistica, vol. 27(2), pages 239-251, June.
    9. Tingting Cui & Pengfei Wang & Wensheng Zhu, 2021. "Covariate-adjusted multiple testing in genome-wide association studies via factorial hidden Markov models," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 30(3), pages 737-757, September.
    10. Noirrit Kiran Chandra & Sourabh Bhattacharya, 2021. "Asymptotic theory of dependent Bayesian multiple testing procedures under possible model misspecification," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 73(5), pages 891-920, October.
    11. Rina Foygel Barber & Aaditya Ramdas, 2017. "The p-filter: multilayer false discovery rate control for grouped hypotheses," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 79(4), pages 1247-1268, September.
    12. Jeong Hwan Kook & Michele Guindani & Linlin Zhang & Marina Vannucci, 2019. "NPBayes-fMRI: Non-parametric Bayesian General Linear Models for Single- and Multi-Subject fMRI Data," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 11(1), pages 3-21, April.
    13. Pan, Lanfeng & Li, Yehua & He, Kevin & Li, Yanming & Li, Yi, 2020. "Generalized linear mixed models with Gaussian mixture random effects: Inference and application," Journal of Multivariate Analysis, Elsevier, vol. 175(C).

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