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Exact‐corrected confidence interval for risk difference in noninferiority binomial trials

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  • Nour Hawila
  • Arthur Berg

Abstract

A novel confidence interval estimator is proposed for the risk difference in noninferiority binomial trials. The proposed confidence interval, which is dependent on the prespecified noninferiority margin, is consistent with an exact unconditional test that preserves the type‐I error and has improved power, particularly for smaller sample sizes, compared to the confidence interval by Chan and Zhang. The improved performance of the proposed confidence interval is theoretically justified and demonstrated with simulations and examples. An R package is also distributed that implements the proposed methods along with other confidence interval estimators.

Suggested Citation

  • Nour Hawila & Arthur Berg, 2023. "Exact‐corrected confidence interval for risk difference in noninferiority binomial trials," Biometrics, The International Biometric Society, vol. 79(2), pages 1133-1144, June.
    • Handle: RePEc:bla:biomet:v:79:y:2023:i:2:p:1133-1144
    DOI: 10.1111/biom.13688
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    References listed on IDEAS

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    1. R. D. Boschloo, 1970. "Raised conditional level of significance for the 2 × 2‐table when testing the equality of two probabilities," Statistica Neerlandica, Netherlands Society for Statistics and Operations Research, vol. 24(1), pages 1-9, March.
    2. Ronald L. Wasserstein & Allen L. Schirm & Nicole A. Lazar, 2019. "Moving to a World Beyond “p," The American Statistician, Taylor & Francis Journals, vol. 73(S1), pages 1-19, March.
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