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Double robust estimation for multiple unordered treatments and clustered observations: Evaluating drug‐eluting coronary artery stents

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  • Sherri Rose
  • Sharon‐Lise Normand

Abstract

Postmarket comparative effectiveness and safety analyses of therapeutic treatments typically involve large observational cohorts. We propose double robust machine learning estimation techniques for implantable medical device evaluations where there are more than two unordered treatments and patients are clustered in hospitals. This flexible approach also accommodates high‐dimensional covariates drawn from clinical databases. The Massachusetts Data Analysis Center percutaneous coronary intervention cohort is used to assess the composite outcome of 10 drug‐eluting stents among adults implanted with at least one drug‐eluting stent in Massachusetts. We find remarkable discrimination between stents. A simulation study designed to mimic this coronary intervention cohort is also presented and produced similar results.

Suggested Citation

  • Sherri Rose & Sharon‐Lise Normand, 2019. "Double robust estimation for multiple unordered treatments and clustered observations: Evaluating drug‐eluting coronary artery stents," Biometrics, The International Biometric Society, vol. 75(1), pages 289-296, March.
    • Handle: RePEc:bla:biomet:v:75:y:2019:i:1:p:289-296
    DOI: 10.1111/biom.12927
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    References listed on IDEAS

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    Cited by:

    1. Irina Degtiar & Tim Layton & Jacob Wallace & Sherri Rose, 2023. "Conditional cross‐design synthesis estimators for generalizability in Medicaid," Biometrics, The International Biometric Society, vol. 79(4), pages 3859-3872, December.

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