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Penalized regression for interval‐censored times of disease progression: Selection of HLA markers in psoriatic arthritis

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  • Ying Wu
  • Richard J. Cook

Abstract

Times of disease progression are interval‐censored when progression status is only known at a series of assessment times. This situation arises routinely in clinical trials and cohort studies when events of interest are only detectable upon imaging, based on blood tests, or upon careful clinical examination. We consider the problem of selecting important prognostic biomarkers from a large set of candidates when disease progression status is only known at irregularly spaced and individual‐specific assessment times. Penalized regression techniques (e.g., LASSO, adaptive LASSO, and SCAD) are adapted to handle interval‐censored time of disease progression. An expectation–maximization algorithm is described which is empirically shown to perform well. Application to the motivating study of the development of arthritis mutilans in patients with psoriatic arthritis is given and several important human leukocyte antigen (HLA) variables are identified for further investigation.

Suggested Citation

  • Ying Wu & Richard J. Cook, 2015. "Penalized regression for interval‐censored times of disease progression: Selection of HLA markers in psoriatic arthritis," Biometrics, The International Biometric Society, vol. 71(3), pages 782-791, September.
    • Handle: RePEc:bla:biomet:v:71:y:2015:i:3:p:782-791
    DOI: 10.1111/biom.12302
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    References listed on IDEAS

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    Cited by:

    1. Ying Wu & Richard J. Cook, 2018. "Variable selection and prediction in biased samples with censored outcomes," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 24(1), pages 72-93, January.
    2. Xu, Yang & Zhao, Shishun & Hu, Tao & Sun, Jianguo, 2021. "Variable selection for generalized odds rate mixture cure models with interval-censored failure time data," Computational Statistics & Data Analysis, Elsevier, vol. 156(C).
    3. Fengting Yi & Niansheng Tang & Jianguo Sun, 2022. "Simultaneous variable selection and estimation for joint models of longitudinal and failure time data with interval censoring," Biometrics, The International Biometric Society, vol. 78(1), pages 151-164, March.
    4. Du, Mingyue & Zhao, Xingqiu & Sun, Jianguo, 2022. "Variable selection for case-cohort studies with informatively interval-censored outcomes," Computational Statistics & Data Analysis, Elsevier, vol. 172(C).

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