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Causation and causal inference in epidemiology

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  • Rothman, K.J.
  • Greenland, S.

Abstract

Concepts of cause and causal inference are largely self-taught from early learning experiences. A model of causation that describes causes in terms of sufficient causes and their component causes illuminates important principles such as multicausality, the dependence of the strength of component causes on the prevalence of complementary component causes, and interaction between component causes. Philosophers agree that causal propositions cannot be proved, and find flaws or practical limitations in all philosophies of causal inference. Hence, the role of logic, belief, and observation in evaluating causal propositions is not settled. Causal inference in epidemiology is better viewed as an exercise in measurement of an effect rather than as a criterion-guided process for deciding whether an effect is present or not.

Suggested Citation

  • Rothman, K.J. & Greenland, S., 2005. "Causation and causal inference in epidemiology," American Journal of Public Health, American Public Health Association, vol. 95(S1), pages 144-150.
  • Handle: RePEc:aph:ajpbhl:10.2105/ajph.2004.059204_2
    DOI: 10.2105/AJPH.2004.059204
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    3. Del Bono, Emilia & Francesconi, Marco & Best, Nicky G., 2011. "Health information and health outcomes: an application of the regression discontinuity design to the 1995 UK contraceptive pill scare case," ISER Working Paper Series 2011-16, Institute for Social and Economic Research.
    4. Steve E Bellan & Juliet R C Pulliam & James C Scott & Jonathan Dushoff & the MMED Organizing Committee, 2012. "How to Make Epidemiological Training Infectious," PLOS Biology, Public Library of Science, vol. 10(4), pages 1-8, April.
    5. Mackenbach, Johan P. & Kulhánová, Ivana & Bopp, Matthias & Deboosere, Patrick & Eikemo, Terje A. & Hoffmann, Rasmus & Kulik, Margarete C. & Leinsalu, Mall & Martikainen, Pekka & Menvielle, Gwenn & Reg, 2015. "Variations in the relation between education and cause-specific mortality in 19 European populations: A test of the “fundamental causes” theory of social inequalities in health," Social Science & Medicine, Elsevier, vol. 127(C), pages 51-62.
    6. Louis Anthony (Tony) Cox & Edward Sanders, 2006. "Estimating Preventable Fractions of Disease Caused by a Specified Biological Mechanism: PAHs in Smoking Lung Cancers as an Example," Risk Analysis, John Wiley & Sons, vol. 26(4), pages 881-892, August.
    7. Nihaya Al-Sheyab & Khalid A Kheirallah & Linda J Thomson Mangnall & Robyn Gallagher, 2015. "Agreement Between Exhaled Breath Carbon Monoxide Threshold Levels and Self-Reported Cigarette Smoking in a Sample of Male Adolescents in Jordan," IJERPH, MDPI, vol. 12(1), pages 1-14, January.
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    10. Ulep, Valerie Gilbert T. & Ortiz, Danica Aisa P. & Go, John Juliard & Duante, Charmaine & Gonzales, Rosa C. & Mendoza, Laurita R. & Reyes, Clarissa & Elgo, Frances Rose & Aldeon, Melanie P., 2012. "Inequities in Noncommunicable Diseases," Discussion Papers DP 2012-04, Philippine Institute for Development Studies.
    11. David Britt & Yung-Chou Chen, 2013. "Increasing the capacity of conceptual diagrams to embrace contextual complexity," Quality & Quantity: International Journal of Methodology, Springer, vol. 47(1), pages 567-576, January.
    12. Högnäs, Robin S. & Bijlsma, Maarten J. & Högnäs, Ulf & Blomqvist, Sandra & Westerlund, Hugo & Hanson, Linda Magnusson, 2022. "It's giving me the blues: A fixed-effects and g-formula approach to understanding job insecurity, sleep disturbances, and major depression," Social Science & Medicine, Elsevier, vol. 297(C).
    13. Rebekah Lydia Miriam Amos & Katie Cresswell & Karen Hughes & Mark A. Bellis, 2023. "ACEtimation—The Combined Effect of Adverse Childhood Experiences on Violence, Health-Harming Behaviors, and Mental Ill-Health: Findings across England and Wales," IJERPH, MDPI, vol. 20(17), pages 1-13, August.
    14. Rafael Quintana, 2023. "Embracing complexity in social science research," Quality & Quantity: International Journal of Methodology, Springer, vol. 57(1), pages 15-38, February.
    15. Nihaya Al-Sheyab & Mahmoud A. Alomari & Smita Shah & Patrick Gallagher & Robyn Gallagher, 2014. "Prevalence, Patterns and Correlates of Cigarette Smoking in Male Adolescents in Northern Jordan, and the Influence of Waterpipe Use and Asthma Diagnosis: A Descriptive Cross-Sectional Study," IJERPH, MDPI, vol. 11(9), pages 1-16, September.
    16. Jean-Baptist du Prel & Johannes Siegrist & Daniela Borchart, 2019. "The Role of Leisure-Time Physical Activity in the Change of Work-Related Stress (ERI) over Time," IJERPH, MDPI, vol. 16(23), pages 1-9, December.
    17. Sime Smolic & Ivan Cipin & Petra Medimurec, 2020. "How is health associated with employment during later working life in Croatia?," Public Sector Economics, Institute of Public Finance, vol. 44(1), pages 99-116.
    18. William Torous & Florian Gunsilius & Philippe Rigollet, 2021. "An Optimal Transport Approach to Estimating Causal Effects via Nonlinear Difference-in-Differences," Papers 2108.05858, arXiv.org, revised Mar 2024.
    19. Baltica Cabieses & Kate E. Pickett & Helena Tunstall, 2012. "Comparing Sociodemographic Factors Associated with Disability Between Immigrants and the Chilean-Born: Are There Different Stories to Tell?," IJERPH, MDPI, vol. 9(12), pages 1-30, December.

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