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Hair Cortisol Concentrations as a Biomarker to Predict a Clinical Pregnancy Outcome after an IVF Cycle: A Pilot Feasibility Study

Author

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  • Diana C. Santa-Cruz

    (Faculty of Health Sciences, Universidad Rey Juan Carlos, Avenida de Atenas, s/n, 28922 Madrid, Spain
    IVI-RMA Madrid, Avenida del Talgo, 68−70, 28023 Madrid, Spain)

  • Rafael A. Caparros-Gonzalez

    (Faculty of Health Sciences, Department of Nursing, University of Granada, 18071 Granada, Spain
    Mind, Brain and Behavior Research Center (CIMCYC), Faculty of Psychology, University of Granada, 18011 Granada, Spain)

  • Borja Romero-Gonzalez

    (Mind, Brain and Behavior Research Center (CIMCYC), Faculty of Psychology, University of Granada, 18011 Granada, Spain
    Faculty of Psychology, Personality, Assessment and Psychological Treatment Department, University of Granada, 18011 Granada, Spain)

  • Maria Isabel Peralta-Ramirez

    (Mind, Brain and Behavior Research Center (CIMCYC), Faculty of Psychology, University of Granada, 18011 Granada, Spain
    Faculty of Psychology, Personality, Assessment and Psychological Treatment Department, University of Granada, 18011 Granada, Spain)

  • Raquel Gonzalez-Perez

    (Department of Pharmacology, CIBERehd, Instituto de Investigación Biosanitaria ibs GRANADA, School of Pharmacy, University of Granada, 18011 Granada, Spain)

  • Juan Antonio García-Velasco

    (Faculty of Health Sciences, Universidad Rey Juan Carlos, Avenida de Atenas, s/n, 28922 Madrid, Spain
    IVI-RMA Madrid, Avenida del Talgo, 68−70, 28023 Madrid, Spain)

Abstract

Our objective was to examine the feasibility of hair cortisol concentrations (HCC) as a biomarker to predict clinical pregnancy outcomes and investigate its potential associations with perceived anxiety, resilience, and depressive symptoms. A total of 43 participants were assessed using HCC, the state trait anxiety inventory (STAI), resilience scale (RS), and the depression subscale of the symptom checklist 90-R (SCL-90-R). Participants were approached at their second consultation with the reproductive endocrinologist (T1), before scheduling their IVF cycle, and then 12 weeks after (T2), at their post-transfer visit with the study coordinators, before the human chorionic gonadotropin (HCG) pregnancy test. The logistic regression model revealed that HCC at T2 predicted 46% of a positive pregnancy test [R2 = 0.46, (ß = 0.11, p < 0.05)]. Pregnant women had higher levels of resilience at T2 (M = 149.29; SD = 17.56) when compared with non-pregnant women at T2 (M = 119.96; SD = 21.71). Significant differences were found between both groups in depression at T2 (t = 3.13, p = 0.01) and resilience at T2 (t = −4.89, p = 0.01). HCC might be a promising biomarker to calculate the probability of pregnancy in women using assisted reproductive technologies (ART).

Suggested Citation

  • Diana C. Santa-Cruz & Rafael A. Caparros-Gonzalez & Borja Romero-Gonzalez & Maria Isabel Peralta-Ramirez & Raquel Gonzalez-Perez & Juan Antonio García-Velasco, 2020. "Hair Cortisol Concentrations as a Biomarker to Predict a Clinical Pregnancy Outcome after an IVF Cycle: A Pilot Feasibility Study," IJERPH, MDPI, vol. 17(9), pages 1-13, April.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:9:p:3020-:d:350873
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    References listed on IDEAS

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