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Unfoldin, A Novel Tool for the Analysis of Protein Misfolding or Neurodegenerative Diseases

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  • Naomi S Hachiya

    (Research and development Department, Tokyo metropolitan Industrial Technology Research Institute, Japan)

Abstract

The achievement of accurate protein folding in living cells is not easy. Many newly synthesized proteins fail to adopt the correct conformation, and such misfolded proteins are more likely to form aggregates. These aggregates lead to the collapse of cellular proteostasis and the formation of inclusion bodies inside or outside the cell membrane, thus exhibiting toxicity to neurons, in particular. This phenomenon has been a major causative factor of neurodegenerative diseases, including protein-misfolding/aggregation diseases.

Suggested Citation

  • Naomi S Hachiya, 2017. "Unfoldin, A Novel Tool for the Analysis of Protein Misfolding or Neurodegenerative Diseases," Open Access Journal of Neurology & Neurosurgery, Juniper Publishers Inc., vol. 6(3), pages 40-44, October.
    • Handle: RePEc:adp:joajnn:v:6:y:2017:i:3:p:40-44
    DOI: 10.19080/OAJNN.2017.06.555686
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    References listed on IDEAS

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    2. Ruedi Aebersold & Matthias Mann, 2003. "Mass spectrometry-based proteomics," Nature, Nature, vol. 422(6928), pages 198-207, March.
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