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Epigenetic Targets in the Treatment of cancer

Author

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  • Giovanni Codacci-Pisanelli

    (Department of Medical and Surgical Sciences and Biotechnology, Sapienza University of Rome, Italy)

Abstract

After the identification of genetic elements in DNA it became apparent that specific cell functions required sophisticated mechanism to regulate gene expression [1]. This is obtained by modifications of DNA and of histones: methyl residues can be inserted on DNA (cytidine) or on histones (lysine or arginine), while acetyl groups on histones are added or removed to turn genes on or off. The epigenetic machinery is very complex consisting of different protein complexes responsible for the different steps required: by applying a simplification that is certainly inaccurate but useful in practical terms, proteins involved in epigenetic regulation can be divided into writers, erasers and readers.

Suggested Citation

  • Giovanni Codacci-Pisanelli, 2017. "Epigenetic Targets in the Treatment of cancer," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 1(4), pages 56-57, June.
    • Handle: RePEc:adp:jnapdd:v:1:y:2017:i:4:p:56-57
    DOI: 10.19080/NAPDD.2017.01.555567
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    References listed on IDEAS

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    1. Lenny Dang & David W. White & Stefan Gross & Bryson D. Bennett & Mark A. Bittinger & Edward M. Driggers & Valeria R. Fantin & Hyun Gyung Jang & Shengfang Jin & Marie C. Keenan & Kevin M. Marks & Rober, 2009. "Cancer-associated IDH1 mutations produce 2-hydroxyglutarate," Nature, Nature, vol. 462(7274), pages 739-744, December.
    2. Edoardo Gaude & Christian Frezza, 2016. "Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival," Nature Communications, Nature, vol. 7(1), pages 1-9, December.
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