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Effects of Endogenous n-3PUFA on Body Weight, Autophagy and Inflammation in Mice

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  • Xin Fang
  • Chao Song
  • YinLin Ge
  • JinYu Zhang

Abstract

The fat-1 transgenic mice were used as models, to investigate the effects of n-3PUFAs on body weight, the expression of inflammation and autophagy in mice, and to explore its mechanism. The mice were divided into two groups: fat-1 transgenic mice and wild-type mice. The body weight and body length were measured and the index of body weight/body length was calculated regularly every week for 8 weeks. Cardiac blood was collected for determination of TG, CT, HDL-C, LDL-C and BG. Frozen sections of liver were stained by Oil Red O to observe the lipid droplets. The expression of autophagy proteins P62, LC3 and ATG7 in the hypothalamus were detected by western blot, and the relative quantitative analysis was performed. Real-time quantitative PCR was used to quantify the mRNA expression of TNF-α, IL-6, IL-1β, IFN-γ, MCP-1, TLR-4 and adiponectin in epididymal adipose tissue. The body weight/body length of fat-1 transgenic mice was significantly lower than that of wild-type mice(P

Suggested Citation

  • Xin Fang & Chao Song & YinLin Ge & JinYu Zhang, 2018. "Effects of Endogenous n-3PUFA on Body Weight, Autophagy and Inflammation in Mice," International Journal of Sciences, Office ijSciences, vol. 7(03), pages 64-70, March.
    • Handle: RePEc:adm:journl:v:7:y:2018:i:3:p:64-70
    DOI: 10.18483/ijSci.1587
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    References listed on IDEAS

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    1. Jing X. Kang & Jingdong Wang & Lin Wu & Zhao B. Kang, 2004. "Fat-1 mice convert n-6 to n-3 fatty acids," Nature, Nature, vol. 427(6974), pages 504-504, February.
    2. Peter G. Kopelman, 2000. "Obesity as a medical problem," Nature, Nature, vol. 404(6778), pages 635-643, April.
    3. Hruby, A. & Manson, J.E. & Qi, L. & Malik, V.S. & Rimm, E.B. & Sun, Q. & Willett, W.C. & Hu, F.B., 2016. "Determinants and consequences of obesity," American Journal of Public Health, American Public Health Association, vol. 106(9), pages 1656-1662.
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