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Bacterial Resistance and the Optimal Use of Antibiotics

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  • Laxminarayan, Ramanan

    (Resources for the Future)

Abstract

The increasing resistance of harmful biological organisms (bacteria, parasites, and pests) to selection pressure from the widespread use of control agents such as antibiotics, antimalarials, and pesticides is a serious problem in both medicine and agriculture. Modeling resistance —or, conversely, the effectiveness of these control agents as a biological resource—yields insights into how these agents should be optimally managed to maximize their economic benefit to society. This paper uses a model of evolution of bacterial resistance to antibiotics—in which resistance places an evolutionary disadvantage on the resistant organism—to develop a simple sequential algorithm of optimal antibiotic use. Although the solution to this problem follows the well-recognized rule of using resources in the order of increasing marginal cost, the unique ways in which these economic costs arise from differing biological traits distinguishes this problem from others in the natural resources arena. This paper also examines the option of periodically rotating between two or more antibiotics and characterizes the economic and biological criteria under which a cycling strategy is superior to simultaneous use of two or more antibiotics.

Suggested Citation

  • Laxminarayan, Ramanan, 2001. "Bacterial Resistance and the Optimal Use of Antibiotics," RFF Working Paper Series dp-01-23, Resources for the Future.
  • Handle: RePEc:rff:dpaper:dp-01-23
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    File URL: http://www.rff.org/RFF/documents/RFF-DP-01-23.pdf
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    References listed on IDEAS

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    3. Laxminarayan, Ramanan & Brown, Gardner M., 2001. "Economics of Antibiotic Resistance: A Theory of Optimal Use," Journal of Environmental Economics and Management, Elsevier, vol. 42(2), pages 183-206, September.
    4. Wirl Franz, 1995. "The Cyclical Exploitation of Renewable Resource Stocks May Be Optimal," Journal of Environmental Economics and Management, Elsevier, vol. 29(2), pages 252-261, September.
    5. Lewis, Tracy R & Schmalensee, Richard, 1977. "Nonconvexity and Optimal Exhaustion of Renewable Resources," International Economic Review, Department of Economics, University of Pennsylvania and Osaka University Institute of Social and Economic Research Association, vol. 18(3), pages 535-552, October.
    6. Weitzman, Martin L., 1976. "The optimal development of resource pools," Journal of Economic Theory, Elsevier, vol. 12(3), pages 351-364, June.
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    Cited by:

    1. John B. Horowitz & H. Brian Moehring, 2004. "How property rights and patents affect antibiotic resistance," Health Economics, John Wiley & Sons, Ltd., vol. 13(6), pages 575-583, June.
    2. Secchi, Silvia, 2000. "Economic issues in resistance management," ISU General Staff Papers 2000010108000013359, Iowa State University, Department of Economics.
    3. Schumacher, Sara K. & Marsh, Thomas L. & Williams, Kimberly A., 2003. "Optimal Pest Control In Floriculture Production Of Ornamental Crops," 2003 Annual Meeting, February 1-5, 2003, Mobile, Alabama 35025, Southern Agricultural Economics Association.
    4. Albert, Jason, 2021. "Strategic dynamics of antibiotic use and the evolution of antibiotic-resistant infections," International Journal of Industrial Organization, Elsevier, vol. 77(C).
    5. Sara K. Schumacher & Thomas L. Marsh & Kimberly A. Williams, 2006. "Optimal pest control in greenhouse production of ornamental crops," Agricultural Economics, International Association of Agricultural Economists, vol. 34(1), pages 39-50, January.
    6. Naveed Chehrazi & Lauren E. Cipriano & Eva A. Enns, 2019. "Dynamics of Drug Resistance: Optimal Control of an Infectious Disease," Operations Research, INFORMS, vol. 67(3), pages 619-650, May.
    7. Ramanan Laxminarayan & R. Simpson, 2002. "Refuge Strategies for Managing Pest Resistance in Transgenic Agriculture," Environmental & Resource Economics, Springer;European Association of Environmental and Resource Economists, vol. 22(4), pages 521-536, August.

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    More about this item

    Keywords

    antibiotic resistance; natural resource; optimization.;
    All these keywords.

    JEL classification:

    • I0 - Health, Education, and Welfare - - General
    • Q0 - Agricultural and Natural Resource Economics; Environmental and Ecological Economics - - General

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