IDEAS home Printed from https://ideas.repec.org/p/hal/journl/hal-03369410.html
   My bibliography  Save this paper

Stochastic asymmetric repartition of lytic machinery in dividing CD8+ T cells generates heterogeneous killing behavior

Author

Listed:
  • Fanny Lafouresse

    (CRCT - Centre de Recherches en Cancérologie de Toulouse - UT3 - Université Toulouse III - Paul Sabatier - UT - Université de Toulouse - INSERM - Institut National de la Santé et de la Recherche Médicale - CNRS - Centre National de la Recherche Scientifique)

  • Romain Jugele

    (CRCT - Centre de Recherches en Cancérologie de Toulouse - UT3 - Université Toulouse III - Paul Sabatier - UT - Université de Toulouse - INSERM - Institut National de la Santé et de la Recherche Médicale - CNRS - Centre National de la Recherche Scientifique)

  • Sabina Müller

    (CRCT - Centre de Recherches en Cancérologie de Toulouse - UT3 - Université Toulouse III - Paul Sabatier - UT - Université de Toulouse - INSERM - Institut National de la Santé et de la Recherche Médicale - CNRS - Centre National de la Recherche Scientifique)

  • Marine Doineau

    (TSE-R - Toulouse School of Economics - UT Capitole - Université Toulouse Capitole - UT - Université de Toulouse - EHESS - École des hautes études en sciences sociales - CNRS - Centre National de la Recherche Scientifique - INRAE - Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement)

  • Valérie Duplan-Eche

    (CPTP - Centre de Physiopathologie Toulouse Purpan - UT3 - Université Toulouse III - Paul Sabatier - UT - Université de Toulouse - INSERM - Institut National de la Santé et de la Recherche Médicale - CNRS - Centre National de la Recherche Scientifique)

  • Eric Espinosa

    (CRCT - Centre de Recherches en Cancérologie de Toulouse - UT3 - Université Toulouse III - Paul Sabatier - UT - Université de Toulouse - INSERM - Institut National de la Santé et de la Recherche Médicale - CNRS - Centre National de la Recherche Scientifique)

  • Marie-Pierre Puissegur

    (CRCT - Centre de Recherches en Cancérologie de Toulouse - UT3 - Université Toulouse III - Paul Sabatier - UT - Université de Toulouse - INSERM - Institut National de la Santé et de la Recherche Médicale - CNRS - Centre National de la Recherche Scientifique)

  • Sébastien Gadat

    (TSE-R - Toulouse School of Economics - UT Capitole - Université Toulouse Capitole - UT - Université de Toulouse - EHESS - École des hautes études en sciences sociales - CNRS - Centre National de la Recherche Scientifique - INRAE - Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement)

  • Salvatore Valitutti

    (CRCT - Centre de Recherches en Cancérologie de Toulouse - UT3 - Université Toulouse III - Paul Sabatier - UT - Université de Toulouse - INSERM - Institut National de la Santé et de la Recherche Médicale - CNRS - Centre National de la Recherche Scientifique, IUCT Oncopole - UMR 1037 - Institut Universitaire du Cancer de Toulouse - Oncopole - UT3 - Université Toulouse III - Paul Sabatier - UT - Université de Toulouse - CHU Toulouse - Centre Hospitalier Universitaire de Toulouse - INSERM - Institut National de la Santé et de la Recherche Médicale)

Abstract

I calibrate a Multiple‐Risk Susceptible–Infected–Recovered model on the covid pandemic to analyze the impact of the age‐specific confinement and polymerase chain reaction (PCR) testing policies on incomes and mortality. Two polar strategies emerge as potentially optimal. The suppression policy would crush the curve by confining 90% of the population for 4 months to eradicate the virus. The flatten‐thecurve policy would reduce the confinement to 30% of the population for 5 months, followed by almost 1 year of free circulation of the virus to attain herd immunity without overwhelming hospitals.Both strategies yield a total cost of around 15% of annual gross domestic product (GDP) when combining the economic cost of confinement with the value of lives lost. I show that hesitating between the two strategies can have a huge societal cost, in particular if the suppression policy is stopped too early. Because seniors are much more vulnerable, a simple recommendation emerges to shelter them as one deconfines young and middle‐aged people to build our collective herd immunity. By doing so, one reduces the death toll of the pandemic together with the economic cost of the confinement, and the total cost is divided by a factor 2. I also show that expanding the mass testing capacity to screen people sent back to work has a large benefit under various scenarios.This analysis is highly dependent upon deeply uncertain epidemiologic, sociological, economic, and ethical parameters.

Suggested Citation

  • Fanny Lafouresse & Romain Jugele & Sabina Müller & Marine Doineau & Valérie Duplan-Eche & Eric Espinosa & Marie-Pierre Puissegur & Sébastien Gadat & Salvatore Valitutti, 2021. "Stochastic asymmetric repartition of lytic machinery in dividing CD8+ T cells generates heterogeneous killing behavior," Post-Print hal-03369410, HAL.
  • Handle: RePEc:hal:journl:hal-03369410
    DOI: 10.7554/eLife.62691
    Note: View the original document on HAL open archive server: https://hal.science/hal-03369410v1
    as

    Download full text from publisher

    File URL: https://hal.science/hal-03369410v1/document
    Download Restriction: no

    File URL: https://libkey.io/10.7554/eLife.62691?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Katherine C. Verbist & Cliff S. Guy & Sandra Milasta & Swantje Liedmann & Marcin M. Kamiński & Ruoning Wang & Douglas R. Green, 2016. "Metabolic maintenance of cell asymmetry following division in activated T lymphocytes," Nature, Nature, vol. 532(7599), pages 389-393, April.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Alexandria C. Wells & Kaito A. Hioki & Constance C. Angelou & Adam C. Lynch & Xueting Liang & Daniel J. Ryan & Iris Thesmar & Saule Zhanybekova & Saulius Zuklys & Jacob Ullom & Agnes Cheong & Jesse Ma, 2023. "Let-7 enhances murine anti-tumor CD8 T cell responses by promoting memory and antagonizing terminal differentiation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Asif A. Dar & Dale D. Kim & Scott M. Gordon & Kathleen Klinzing & Siera Rosen & Ipsita Guha & Nadia Porter & Yohaniz Ortega & Katherine S. Forsyth & Jennifer Roof & Hossein Fazelinia & Lynn A. Spruce , 2023. "c-Myc uses Cul4b to preserve genome integrity and promote antiviral CD8+ T cell immunity," Nature Communications, Nature, vol. 14(1), pages 1-21, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:hal:journl:hal-03369410. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: CCSD (email available below). General contact details of provider: https://hal.archives-ouvertes.fr/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.