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Metabolic maintenance of cell asymmetry following division in activated T lymphocytes

Author

Listed:
  • Katherine C. Verbist

    (St. Jude Children’s Research Hospital)

  • Cliff S. Guy

    (St. Jude Children’s Research Hospital)

  • Sandra Milasta

    (St. Jude Children’s Research Hospital)

  • Swantje Liedmann

    (St. Jude Children’s Research Hospital)

  • Marcin M. Kamiński

    (St. Jude Children’s Research Hospital)

  • Ruoning Wang

    (Center for Childhood Cancer and Blood Disease, The Research Institute at Nationwide Children’s Hospital)

  • Douglas R. Green

    (St. Jude Children’s Research Hospital)

Abstract

The asymmetric distribution of mTORC1 and c-Myc in the first division of daughter cells of activated CD8 T cells affects the proliferation, metabolism and differentiation potential of their progeny.

Suggested Citation

  • Katherine C. Verbist & Cliff S. Guy & Sandra Milasta & Swantje Liedmann & Marcin M. Kamiński & Ruoning Wang & Douglas R. Green, 2016. "Metabolic maintenance of cell asymmetry following division in activated T lymphocytes," Nature, Nature, vol. 532(7599), pages 389-393, April.
    • Handle: RePEc:nat:nature:v:532:y:2016:i:7599:d:10.1038_nature17442
    DOI: 10.1038/nature17442
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    Cited by:

    1. Alexandria C. Wells & Kaito A. Hioki & Constance C. Angelou & Adam C. Lynch & Xueting Liang & Daniel J. Ryan & Iris Thesmar & Saule Zhanybekova & Saulius Zuklys & Jacob Ullom & Agnes Cheong & Jesse Ma, 2023. "Let-7 enhances murine anti-tumor CD8 T cell responses by promoting memory and antagonizing terminal differentiation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Asif A. Dar & Dale D. Kim & Scott M. Gordon & Kathleen Klinzing & Siera Rosen & Ipsita Guha & Nadia Porter & Yohaniz Ortega & Katherine S. Forsyth & Jennifer Roof & Hossein Fazelinia & Lynn A. Spruce , 2023. "c-Myc uses Cul4b to preserve genome integrity and promote antiviral CD8+ T cell immunity," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    3. Fanny Lafouresse & Romain Jugele & Sabina Müller & Marine Doineau & Valérie Duplan-Eche & Eric Espinosa & Marie-Pierre Puissegur & Sébastien Gadat & Salvatore Valitutti, 2021. "Stochastic asymmetric repartition of lytic machinery in dividing CD8+ T cells generates heterogeneous killing behavior," Post-Print hal-03369410, HAL.

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