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APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population

Author

Listed:
  • Angela Garcia
  • Caleb Finch
  • Margaret Gatz
  • Thomas S. Kraft
  • Daniel Eid Rodriguez
  • Daniel Cummings
  • Mia Charifson
  • Kenneth Buetow
  • Bret A. Beheim
  • Hooman Allayee
  • Gregory Thomas
  • Jonathan Stieglitz

    (IAST - Institute for Advanced Study in Toulouse, UT Capitole - Université Toulouse Capitole - UT - Université de Toulouse)

  • Michael Gurven
  • Hillard Kaplan
  • Benjamin C. Trumble

Abstract

In post-industrial settings, apolipoprotein E4 (APOE4) is associated with increased cardiovascular and neurological disease risk. However, the majority of human evolutionary history occurred in environments with higher pathogenic diversity and low cardiovascular risk. We hypothesize that in high-pathogen and energy-limited contexts, the APOE4 allele confers benefits by reducing innate inflammation when uninfected, while maintaining higher lipid levels that buffer costs of immune activation during infection. Among Tsimane forager-farmers of Bolivia (N = 1266, 50% female), APOE4 is associated with 30% lower C-reactive protein, and higher total cholesterol and oxidized LDL. Blood lipids were either not associated, or negatively associated with inflammatory biomarkers, except for associations of oxidized LDL and inflammation which were limited to obese adults. Further, APOE4 carriers maintain higher levels of total and LDL cholesterol at low body mass indices (BMIs). These results suggest that the relationship between APOE4 and lipids may be beneficial for pathogen-driven immune responses and unlikely to increase cardiovascular risk in an active subsistence population.

Suggested Citation

  • Angela Garcia & Caleb Finch & Margaret Gatz & Thomas S. Kraft & Daniel Eid Rodriguez & Daniel Cummings & Mia Charifson & Kenneth Buetow & Bret A. Beheim & Hooman Allayee & Gregory Thomas & Jonathan St, 2021. "APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population," Post-Print hal-03364139, HAL.
  • Handle: RePEc:hal:journl:hal-03364139
    DOI: 10.7554/eLife.68231
    Note: View the original document on HAL open archive server: https://hal.science/hal-03364139
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    References listed on IDEAS

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    1. Rosinger, Asher & Tanner, Susan & Leonard, William R., 2013. "Precursors to overnutrition: The effects of household market food expenditures on measures of body composition among Tsimane' adults in lowland Bolivia," Social Science & Medicine, Elsevier, vol. 92(C), pages 53-60.
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