IDEAS home Printed from https://ideas.repec.org/p/bep/ucbbio/1148.html
   My bibliography  Save this paper

Mean Response Models of Repeated Measurements in Presence of Varying Effectiveness Onset

Author

Listed:
  • Ying Chen

    (Division of Biostatistics, School of Public Health, University of California, Berkeley)

  • Su-Chun Cheng

    (Department of Epidemiology & Biostatistics, University of California, San Francisco)

Abstract

Repeated measurements are often collected over time to evaluate treatment efficacy in clinical trials. Most of the statistical models of the repeated measurements have been focusing on their mean response as function of time. These models usually assume that the treatment has persistent effect of constant additivity or multiplicity on the mean response functions throughout the observation period of time. In reality, however, such assumption may be confounded by the potential existence of the so-called effectiveness action onset, although they are often unobserved or difficult to obtain. Instead of including nonparametric time-varying coefficients in the mean response models, we propose and study some semiparametric mean response models to accommodate such effectiveness times. Our methodologies will be demonstrated by a real randomised clinical trial data.

Suggested Citation

  • Ying Chen & Su-Chun Cheng, 2004. "Mean Response Models of Repeated Measurements in Presence of Varying Effectiveness Onset," U.C. Berkeley Division of Biostatistics Working Paper Series 1148, Berkeley Electronic Press.
  • Handle: RePEc:bep:ucbbio:1148
    Note: oai:bepress.com:ucbbiostat-1148
    as

    Download full text from publisher

    File URL: http://www.bepress.com/cgi/viewcontent.cgi?article=1148&context=ucbbiostat
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Chiang C-T. & Rice J. A & Wu C. O, 2001. "Smoothing Spline Estimation for Varying Coefficient Models With Repeatedly Measured Dependent Variables," Journal of the American Statistical Association, American Statistical Association, vol. 96, pages 605-619, June.
    2. Lin D Y & Ying Z, 2001. "Semiparametric and Nonparametric Regression Analysis of Longitudinal Data," Journal of the American Statistical Association, American Statistical Association, vol. 96, pages 103-126, March.
    3. Jianhua Z. Huang, 2002. "Varying-coefficient models and basis function approximations for the analysis of repeated measurements," Biometrika, Biometrika Trust, vol. 89(1), pages 111-128, March.
    4. Y. Q. Chen, 2002. "Additive hazards models with latent treatment effectiveness lag time," Biometrika, Biometrika Trust, vol. 89(4), pages 917-931, December.
    5. Yatchew, A., 1997. "An elementary estimator of the partial linear model," Economics Letters, Elsevier, vol. 57(2), pages 135-143, December.
    6. J. Sun & L. J. Wei, 2000. "Regression analysis of panel count data with covariate‐dependent observation and censoring times," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 62(2), pages 293-302.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Li, XiaoLi & You, JinHong, 2012. "Error covariance matrix correction based approach to functional coefficient regression models with generated covariates," Journal of Multivariate Analysis, Elsevier, vol. 107(C), pages 263-281.
    2. Daowen Zhang, 2004. "Generalized Linear Mixed Models with Varying Coefficients for Longitudinal Data," Biometrics, The International Biometric Society, vol. 60(1), pages 8-15, March.
    3. Ye, Mao & Lu, Zhao-Hua & Li, Yimei & Song, Xinyuan, 2019. "Finite mixture of varying coefficient model: Estimation and component selection," Journal of Multivariate Analysis, Elsevier, vol. 171(C), pages 452-474.
    4. Yijun Wang & Weiwei Wang, 2021. "Quantile estimation of semiparametric model with time-varying coefficients for panel count data," PLOS ONE, Public Library of Science, vol. 16(12), pages 1-18, December.
    5. Wang, Qihua & Zhang, Riquan, 2009. "Statistical estimation in varying coefficient models with surrogate data and validation sampling," Journal of Multivariate Analysis, Elsevier, vol. 100(10), pages 2389-2405, November.
    6. Olga Klopp & Marianna Pensky, 2013. "Sparse High-dimensional Varying Coefficient Model : Non-asymptotic Minimax Study," Working Papers 2013-30, Center for Research in Economics and Statistics.
    7. Xing-cai Zhou & Jin-Guan Lin, 2014. "Empirical likelihood for varying-coefficient semiparametric mixed-effects errors-in-variables models with longitudinal data," Statistical Methods & Applications, Springer;Società Italiana di Statistica, vol. 23(1), pages 51-69, March.
    8. Zhao, Xingqiu & Tong, Xingwei, 2011. "Semiparametric regression analysis of panel count data with informative observation times," Computational Statistics & Data Analysis, Elsevier, vol. 55(1), pages 291-300, January.
    9. Tang Qingguo & Cheng Longsheng, 2008. "M-estimation and B-spline approximation for varying coefficient models with longitudinal data," Journal of Nonparametric Statistics, Taylor & Francis Journals, vol. 20(7), pages 611-625.
    10. Zhao, Xingqiu & Tong, Xingwei & Sun, Jianguo, 2013. "Robust estimation for panel count data with informative observation times," Computational Statistics & Data Analysis, Elsevier, vol. 57(1), pages 33-40.
    11. Qiu, Jia & Li, Degao & You, Jinhong, 2015. "SCAD-penalized regression for varying-coefficient models with autoregressive errors," Journal of Multivariate Analysis, Elsevier, vol. 137(C), pages 100-118.
    12. Wang, Qihua & Xue, Liugen, 2011. "Statistical inference in partially-varying-coefficient single-index model," Journal of Multivariate Analysis, Elsevier, vol. 102(1), pages 1-19, January.
    13. Stefan Stremersch & Aurélie Lemmens, 2009. "Sales Growth of New Pharmaceuticals Across the Globe: The Role of Regulatory Regimes," Marketing Science, INFORMS, vol. 28(4), pages 690-708, 07-08.
    14. Chen, Xuerong & Tang, Niansheng & Zhou, Yong, 2016. "Quantile regression of longitudinal data with informative observation times," Journal of Multivariate Analysis, Elsevier, vol. 144(C), pages 176-188.
    15. Wang-Li Xu & Li-Xing Zhu, 2008. "Goodness-of-fit testing for varying-coefficient models," Metrika: International Journal for Theoretical and Applied Statistics, Springer, vol. 68(2), pages 129-146, September.
    16. Colin Wu & Xin Tian & Jarvis Yu, 2010. "Nonparametric estimation for time-varying transformation models with longitudinal data," Journal of Nonparametric Statistics, Taylor & Francis Journals, vol. 22(2), pages 133-147.
    17. Lian, Heng, 2015. "Quantile regression for dynamic partially linear varying coefficient time series models," Journal of Multivariate Analysis, Elsevier, vol. 141(C), pages 49-66.
    18. Wangli Xu & Lixing Zhu, 2013. "Testing the adequacy of varying coefficient models with missing responses at random," Metrika: International Journal for Theoretical and Applied Statistics, Springer, vol. 76(1), pages 53-69, January.
    19. Yiqiang Lu & Riquan Zhang, 2009. "Smoothing spline estimation of generalised varying-coefficient mixed model," Journal of Nonparametric Statistics, Taylor & Francis Journals, vol. 21(7), pages 815-825.
    20. Lijie Gu & Li Wang & Wolfgang Härdle & Lijian Yang, 2014. "A simultaneous confidence corridor for varying coefficient regression with sparse functional data," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 23(4), pages 806-843, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:bep:ucbbio:1148. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Christopher F. Baum (email available below). General contact details of provider: http://www.bepress.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.