IDEAS home Printed from https://ideas.repec.org/a/wly/riskan/v35y2015i4p676-700.html
   My bibliography  Save this article

Reanalysis of the DEMS Nested Case‐Control Study of Lung Cancer and Diesel Exhaust: Suitability for Quantitative Risk Assessment

Author

Listed:
  • Kenny S. Crump
  • Cynthia Van Landingham
  • Suresh H. Moolgavkar
  • Roger McClellan

Abstract

The International Agency for Research on Cancer (IARC) in 2012 upgraded its hazard characterization of diesel engine exhaust (DEE) to “carcinogenic to humans.” The Diesel Exhaust in Miners Study (DEMS) cohort and nested case‐control studies of lung cancer mortality in eight U.S. nonmetal mines were influential in IARC's determination. We conducted a reanalysis of the DEMS case‐control data to evaluate its suitability for quantitative risk assessment (QRA). Our reanalysis used conditional logistic regression and adjusted for cigarette smoking in a manner similar to the original DEMS analysis. However, we included additional estimates of DEE exposure and adjustment for radon exposure. In addition to applying three DEE exposure estimates developed by DEMS, we applied six alternative estimates. Without adjusting for radon, our results were similar to those in the original DEMS analysis: all but one of the nine DEE exposure estimates showed evidence of an association between DEE exposure and lung cancer mortality, with trend slopes differing only by about a factor of two. When exposure to radon was adjusted, the evidence for a DEE effect was greatly diminished, but was still present in some analyses that utilized the three original DEMS DEE exposure estimates. A DEE effect was not observed when the six alternative DEE exposure estimates were utilized and radon was adjusted. No consistent evidence of a DEE effect was found among miners who worked only underground. This article highlights some issues that should be addressed in any use of the DEMS data in developing a QRA for DEE.

Suggested Citation

  • Kenny S. Crump & Cynthia Van Landingham & Suresh H. Moolgavkar & Roger McClellan, 2015. "Reanalysis of the DEMS Nested Case‐Control Study of Lung Cancer and Diesel Exhaust: Suitability for Quantitative Risk Assessment," Risk Analysis, John Wiley & Sons, vol. 35(4), pages 676-700, April.
    • Handle: RePEc:wly:riskan:v:35:y:2015:i:4:p:676-700
    DOI: 10.1111/risa.12371
    as

    Download full text from publisher

    File URL: https://doi.org/10.1111/risa.12371
    Download Restriction: no
    File URL: https://libkey.io/10.1111/risa.12371?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Stanley V. Dawson & George V. Alexeeff, 2001. "Multi‐Stage Model Estimates of Lung Cancer Risk from Exposure to Diesel Exhaust, Based on a U.S. Railroad Worker Cohort," Risk Analysis, John Wiley & Sons, vol. 21(1), pages 1-18, February.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Gretchen Stevens & Andrew Wilson & James K. Hammitt, 2005. "A Benefit‐Cost Analysis of Retrofitting Diesel Vehicles with Particulate Filters in the Mexico City Metropolitan Area," Risk Analysis, John Wiley & Sons, vol. 25(4), pages 883-899, August.
    2. Suresh H. Moolgavkar & Ellen T. Chang & Georg Luebeck & Edmund C. Lau & Heather N. Watson & Kenny S. Crump & Paolo Boffetta & Roger McClellan, 2015. "Diesel Engine Exhaust and Lung Cancer Mortality: Time‐Related Factors in Exposure and Risk," Risk Analysis, John Wiley & Sons, vol. 35(4), pages 663-675, April.
    3. Yi Sun & Frank Bochmann & Annette Nold & Markus Mattenklott, 2014. "Diesel Exhaust Exposure and the Risk of Lung Cancer—A Review of the Epidemiological Evidence," IJERPH, MDPI, vol. 11(2), pages 1-29, January.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:wly:riskan:v:35:y:2015:i:4:p:676-700. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Wiley Content Delivery (email available below). General contact details of provider: https://doi.org/10.1111/(ISSN)1539-6924 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.