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Diesel Exhaust Exposure and the Risk of Lung Cancer—A Review of the Epidemiological Evidence

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Listed:
  • Yi Sun

    (Institute for Occupational Safety and Health of the German Social Accident Insurance (IFA), Alte Heerstraße 111, Sankt Augustin 53773, Germany)

  • Frank Bochmann

    (Institute for Occupational Safety and Health of the German Social Accident Insurance (IFA), Alte Heerstraße 111, Sankt Augustin 53773, Germany
    These authors contributed equally to this work.)

  • Annette Nold

    (Institute for Occupational Safety and Health of the German Social Accident Insurance (IFA), Alte Heerstraße 111, Sankt Augustin 53773, Germany
    These authors contributed equally to this work.)

  • Markus Mattenklott

    (Institute for Occupational Safety and Health of the German Social Accident Insurance (IFA), Alte Heerstraße 111, Sankt Augustin 53773, Germany
    These authors contributed equally to this work.)

Abstract

To critically evaluate the association between diesel exhaust (DE) exposure and the risk of lung cancer, we conducted a systematic review of published epidemiological evidences. To comprehensively identify original studies on the association between DE exposure and the risk of lung cancer, literature searches were performed in literature databases for the period between 1970 and 2013, including bibliographies and cross-referencing. In total, 42 cohort studies and 32 case-control studies were identified in which the association between DE exposures and lung cancer was examined. In general, previous studies suffer from a series of methodological limitations, including design, exposure assessment methods and statistical analysis used. A lack of objective exposure information appears to be the main problem in interpreting epidemiological evidence. To facilitate the interpretation and comparison of previous studies, a job-exposure matrix (JEM) of DE exposures was created based on around 4,000 historical industrial measurements. The values from the JEM were considered during interpretation and comparison of previous studies. Overall, neither cohort nor case-control studies indicate a clear exposure-response relationship between DE exposure and lung cancer. Epidemiological studies published to date do not allow a valid quantification of the association between DE and lung cancer.

Suggested Citation

  • Yi Sun & Frank Bochmann & Annette Nold & Markus Mattenklott, 2014. "Diesel Exhaust Exposure and the Risk of Lung Cancer—A Review of the Epidemiological Evidence," IJERPH, MDPI, vol. 11(2), pages 1-29, January.
    • Handle: RePEc:gam:jijerp:v:11:y:2014:i:2:p:1312-1340:d:32526
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    References listed on IDEAS

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    1. Stanley V. Dawson & George V. Alexeeff, 2001. "Multi‐Stage Model Estimates of Lung Cancer Risk from Exposure to Diesel Exhaust, Based on a U.S. Railroad Worker Cohort," Risk Analysis, John Wiley & Sons, vol. 21(1), pages 1-18, February.
    2. Steenland, N.K. & Silverman, D.T. & Hornung, R.W., 1990. "Case-control study of lung cancer and truck driving in the teamsters union," American Journal of Public Health, American Public Health Association, vol. 80(6), pages 670-674.
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    Cited by:

    1. Neil J. Hime & Guy B. Marks & Christine T. Cowie, 2018. "A Comparison of the Health Effects of Ambient Particulate Matter Air Pollution from Five Emission Sources," IJERPH, MDPI, vol. 15(6), pages 1-24, June.

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