IDEAS home Printed from https://ideas.repec.org/a/wly/riskan/v30y2010i8p1240-1248.html
   My bibliography  Save this article

Potency Factors for Risk Assessment at Libby, Montana

Author

Listed:
  • Suresh H. Moolgavkar
  • Jay Turim
  • Dominik D. Alexander
  • Edmund C. Lau
  • Colleen A. Cushing

Abstract

We reanalyzed the Libby vermiculite miners’ cohort assembled by Sullivan to estimate potency factors for lung cancer, mesothelioma, nonmalignant respiratory disease (NMRD), and all‐cause mortality associated with exposure to Libby fibers. Our principal statistical tool for analyses of lung cancer, NMRD, and total mortality in the cohort was the time‐dependent proportional hazards model. For mesothelioma, we used an extension of the Peto formula. For a cumulative exposure to Libby fiber of 100 f/mL‐yr, our estimates of relative risk (RR) are as follows: lung cancer, RR = 1.12, 95% confidence interval (CI) =[1.06, 1.17]; NMRD, RR = 1.14, 95% CI =[1.09, 1.18]; total mortality, RR = 1.06, 95% CI =[1.04, 1.08]. These estimates were virtually identical when analyses were restricted to the subcohort of workers who were employed for at least one year. For mesothelioma, our estimate of potency is KM = 0.5 × 10−8, 95% CI =[0.3 × 10−8, 0.8 × 10−8]. Finally, we estimated the mortality ratios standardized against the U.S. population for lung cancer, NMRD, and total mortality and obtained estimates that were in good agreement with those reported by Sullivan. The estimated potency factors form the basis for a quantitative risk assessment at Libby.

Suggested Citation

  • Suresh H. Moolgavkar & Jay Turim & Dominik D. Alexander & Edmund C. Lau & Colleen A. Cushing, 2010. "Potency Factors for Risk Assessment at Libby, Montana," Risk Analysis, John Wiley & Sons, vol. 30(8), pages 1240-1248, August.
    • Handle: RePEc:wly:riskan:v:30:y:2010:i:8:p:1240-1248
    DOI: 10.1111/j.1539-6924.2010.01411.x
    as

    Download full text from publisher

    File URL: https://doi.org/10.1111/j.1539-6924.2010.01411.x
    Download Restriction: no
    File URL: https://libkey.io/10.1111/j.1539-6924.2010.01411.x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. D. Wayne Berman & Kenny S. Crump & Eric J. Chatfield & John M.G. Davis & Alan D. Jones, 1995. "The Sizes, Shapes, and Mineralogy of Asbestos Structures that Induce Lung Tumors or Mesothelioma in AF/HAN Rats Following Inhalation," Risk Analysis, John Wiley & Sons, vol. 15(2), pages 181-195, April.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. William J. McCarthy & Rafael Meza & Jihyoun Jeon & Suresh H. Moolgavkar, 2012. "Chapter 6: Lung Cancer in Never Smokers: Epidemiology and Risk Prediction Models," Risk Analysis, John Wiley & Sons, vol. 32(s1), pages 69-84, August.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. D. Wayne Berman, 2011. "Apples to Apples: The Origin and Magnitude of Differences in Asbestos Cancer Risk Estimates Derived Using Varying Protocols," Risk Analysis, John Wiley & Sons, vol. 31(8), pages 1308-1326, August.
    2. Patrick A. Hessel & M. Jane Teta & Michael Goodman & Edmund Lau, 2004. "Mesothelioma Among Brake Mechanics: An Expanded Analysis of a Case‐Control Study," Risk Analysis, John Wiley & Sons, vol. 24(3), pages 547-552, June.
    3. Suresh H. Moolgavkar & E. Georg Luebeck & Jay Turim & Linda Hanna, 1999. "Quantitative Assessment of the Risk of Lung Cancer Associated with Occupational Exposure to Refractory Ceramic Fibers," Risk Analysis, John Wiley & Sons, vol. 19(4), pages 599-611, August.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:wly:riskan:v:30:y:2010:i:8:p:1240-1248. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Wiley Content Delivery (email available below). General contact details of provider: https://doi.org/10.1111/(ISSN)1539-6924 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.