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A Multistage Model of Carcinogenesis Incorporating DNA Damage and Repair

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  • C. J. Portier
  • A. Kopp‐Schneide

Abstract

Mathematical models of carcinogenesis are one tool used for research into the mechanisms of carcinogenesis and for assessing risks from exposure to carcinogenic agents. Recent research into carcinogenic mechanisms has focused on the role of cell replication in fixing damage to cellular DNA and increasing the incidence of malignancies. The most commonly used multistage model of carcinogenesis does not explicitly account for DNA damage and the contribution of cell replication rates on the transformation of cells through the various stages. In this manuscript, a generalized multistage model of carcinogenesis is developed in which DNA damage, cell replication, and DNA repair are explicitly included.

Suggested Citation

  • C. J. Portier & A. Kopp‐Schneide, 1991. "A Multistage Model of Carcinogenesis Incorporating DNA Damage and Repair," Risk Analysis, John Wiley & Sons, vol. 11(3), pages 535-543, September.
    • Handle: RePEc:wly:riskan:v:11:y:1991:i:3:p:535-543
    DOI: 10.1111/j.1539-6924.1991.tb00639.x
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    References listed on IDEAS

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    1. Suresh Moolgavkar & Anup Dewanji, 1988. "Biologically Based Models for Cancer Risk Assessment: A Cautionary Note," Risk Analysis, John Wiley & Sons, vol. 8(1), pages 5-6, March.
    2. Suresh H. Moolgavkar & Anup Dewanji & David J. Venzon, 1988. "A Stochastic Two‐Stage Model for Cancer Risk Assessment. I. The Hazard Function and the Probability of Tumor," Risk Analysis, John Wiley & Sons, vol. 8(3), pages 383-392, September.
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    Cited by:

    1. A. John Bailer & Walter W. Piegorsch, 2000. "From Quantal Counts to Mechanisms and Systems: The Past, Present, and Future of Biometrics in Environmental Toxicology," Biometrics, The International Biometric Society, vol. 56(2), pages 327-336, June.
    2. Michael Greenberg & Charles Haas & Anthony Cox & Karen Lowrie & Katherine McComas & Warner North, 2012. "Ten Most Important Accomplishments in Risk Analysis, 1980–2010," Risk Analysis, John Wiley & Sons, vol. 32(5), pages 771-781, May.
    3. Wolfgang F. Heidenreich & E. Georg Luebeck & Suresh H. Moolgavkar, 1997. "Some Properties of the Hazard Function of the Two‐Mutation Clonal Expansion Model," Risk Analysis, John Wiley & Sons, vol. 17(3), pages 391-399, June.
    4. Chao W. Chen, 1993. "Armitage‐Doll Two‐Stage Model: Implications and Extension," Risk Analysis, John Wiley & Sons, vol. 13(3), pages 273-279, June.
    5. Annette Kopp‐Schneider & Christopher J. Portier & Claire D. Sherman, 1994. "The Exact Formula for Tumor Incidence in the Two‐Stage Model," Risk Analysis, John Wiley & Sons, vol. 14(6), pages 1079-1080, December.

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