IDEAS home Printed from https://ideas.repec.org/a/wly/riskan/v11y1991i1p149-157.html
   My bibliography  Save this article

Stochastic Analysis of Intermediate Lesions in Carcinogenesis Experiments

Author

Listed:
  • E. Georg Luebeck
  • Suresh H. Moolgavkar

Abstract

In many animal model systems for carcinogenesis, well characterized putative premalignant lesions are observed. A much studied example is provided by the enzyme altered foci in rodent hepatocarcinogenesis experiments. In a recent paper, we proposed a method for the quantitative analysis of such premalignant lesions. The model used in that paper assumed that the mean growth of premalignant clones is exponential. However, it has been suggested that such a model is oversimplified. In this paper, we relax the assumption of exponential mean growth. The new model contains one extra parameter that measures departures from exponentiality. Use of the model is illustrated by analysis of ATPase deficient foci in the liver of rats given NNM (N‐nitrosomorpholine) in their drinking water. The analysis suggests that the clonal growth of altered cells is significantly accelerated (superexponential) for nontoxic doses of NNM. Finally, the hazard function of the two‐mutation model for carcinogenesis is briefly discussed under nonexponential (mean) growth of intermediate cells.

Suggested Citation

  • E. Georg Luebeck & Suresh H. Moolgavkar, 1991. "Stochastic Analysis of Intermediate Lesions in Carcinogenesis Experiments," Risk Analysis, John Wiley & Sons, vol. 11(1), pages 149-157, March.
  • Handle: RePEc:wly:riskan:v:11:y:1991:i:1:p:149-157
    DOI: 10.1111/j.1539-6924.1991.tb00585.x
    as

    Download full text from publisher

    File URL: https://doi.org/10.1111/j.1539-6924.1991.tb00585.x
    Download Restriction: no

    File URL: https://libkey.io/10.1111/j.1539-6924.1991.tb00585.x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Anup Dewanji & Jihyoun Jeon & Rafael Meza & E Georg Luebeck, 2011. "Number and Size Distribution of Colorectal Adenomas under the Multistage Clonal Expansion Model of Cancer," PLOS Computational Biology, Public Library of Science, vol. 7(10), pages 1-10, October.
    2. Wolfgang F. Heidenreich, 2005. "Heterogeneity of Cancer Risk Due to Stochastic Effects," Risk Analysis, John Wiley & Sons, vol. 25(6), pages 1589-1594, December.
    3. Claire D. Sherman & Chnstopher J. Portier, 1998. "Eyes Closed: Simple, Intuitive, Statistically Sound, and Efficient Methods for Estimating Parameters of Clonal Growth Cancer Models," Risk Analysis, John Wiley & Sons, vol. 18(5), pages 529-534, October.
    4. Suresh H. Moolgavkar, 1994. "Biological Models of Carcinogenesis and Quantitative Cancer Risk Assessment," Risk Analysis, John Wiley & Sons, vol. 14(6), pages 879-882, December.
    5. David A. Kramer & Rory B. Conolly, 1997. "Computer Simulation of Clonal Growth Cancer Models. I. Parameter Estimation Using an Iterative Absolute Bisection Algorithm," Risk Analysis, John Wiley & Sons, vol. 17(1), pages 115-126, February.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:wly:riskan:v:11:y:1991:i:1:p:149-157. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Wiley Content Delivery (email available below). General contact details of provider: https://doi.org/10.1111/(ISSN)1539-6924 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.