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Modelling Mutation to a Cytotoxic T-lymphocyte HIV Vaccine

Author

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  • BERNHARD KONRAD
  • NAVEEN VAIDYA
  • ROBERT SMITH?

Abstract

Resistance to a postinfection HIV vaccine that stimulates cytotoxic T-lymphocytes (CTLs) depends on the relationship between the vaccine strength, the fitness cost of the mutant strain, and the rate of mutant escape. If the vaccine is strong enough, both strains of the virus should be controlled by administering the vaccine sufficiently often. However, if escape mutation to the vaccine occurs, then either the wild type or the mutant can outcompete the other strain. Imperfect adherence may result in the persistence of the mutant, while fluctuations in the vaccination time—even if no vaccines are missed—may result in the mutant outcompeting the wild type.

Suggested Citation

  • Bernhard Konrad & Naveen Vaidya & Robert Smith?, 2011. "Modelling Mutation to a Cytotoxic T-lymphocyte HIV Vaccine," Mathematical Population Studies, Taylor & Francis Journals, vol. 18(2), pages 122-149.
    • Handle: RePEc:taf:mpopst:v:18:y:2011:i:2:p:122-149
    DOI: 10.1080/08898480.2011.564566
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    References listed on IDEAS

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    1. Dan H. Barouch & Jennifer Kunstman & Marcelo J. Kuroda & Jörn E. Schmitz & Sampa Santra & Fred W. Peyerl & Georgia R. Krivulka & Kristin Beaudry & Michelle A. Lifton & Darci A. Gorgone & David C. Mont, 2002. "Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes," Nature, Nature, vol. 415(6869), pages 335-339, January.
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