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HIV-1 Dynamics In Vivo: Virion Clearance Rate, Infected Cell Lifespan, and Viral Generation Time

Author

Listed:
  • Alan S. Perelson
  • Avidan U. Neumann
  • Martin Markowitz
  • John M. Leonard
  • David D. Ho

Abstract

Using a new mathematical model to analyze a detailed set of viral load data collected from five infected patients after the administration of a potent inhibitor of HIV-1 protease, it was estimated that productively infected cells have, on average, a lifespan of 2.2 days (t[sub 1/2]=1.6 days) and that plasma virions have a mean lifespan of 0.3 days (t[sub 1/2]=0.24 days). The average total HIV-1 production was 10.3 x 10[super 9} virions per day, which is substantially higher than previous minimum estimates. Our results also suggest that the minimum duration of the HIV-1 life cycle in vivo is 1.2 days on average, and that the average HIV-1 generation time, defined as the time from release of a virion until it infects another cell and causes the release of a new generation of viral particles, is 2.6 days. These findings on viral dynamics provide not only a kinetic picture ofHIV-1 pathogenesis, but also the theoretical principles to guide treatment strategies.

Suggested Citation

  • Alan S. Perelson & Avidan U. Neumann & Martin Markowitz & John M. Leonard & David D. Ho, 1996. "HIV-1 Dynamics In Vivo: Virion Clearance Rate, Infected Cell Lifespan, and Viral Generation Time," Working Papers 96-02-004, Santa Fe Institute.
    • Handle: RePEc:wop:safiwp:96-02-004
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