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A Bayesian Approach for Estimating Dynamic Functional Network Connectivity in fMRI Data

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  • Ryan Warnick
  • Michele Guindani
  • Erik Erhardt
  • Elena Allen
  • Vince Calhoun
  • Marina Vannucci

Abstract

Dynamic functional connectivity, that is, the study of how interactions among brain regions change dynamically over the course of an fMRI experiment, has recently received wide interest in the neuroimaging literature. Current approaches for studying dynamic connectivity often rely on ad hoc approaches for inference, with the fMRI time courses segmented by a sequence of sliding windows. We propose a principled Bayesian approach to dynamic functional connectivity, which is based on the estimation of time varying networks. Our method utilizes a hidden Markov model for classification of latent cognitive states, achieving estimation of the networks in an integrated framework that borrows strength over the entire time course of the experiment. Furthermore, we assume that the graph structures, which define the connectivity states at each time point, are related within a super-graph, to encourage the selection of the same edges among related graphs. We apply our method to simulated task -based fMRI data, where we show how our approach allows the decoupling of the task-related activations and the functional connectivity states. We also analyze data from an fMRI sensorimotor task experiment on an individual healthy subject and obtain results that support the role of particular anatomical regions in modulating interaction between executive control and attention networks.

Suggested Citation

  • Ryan Warnick & Michele Guindani & Erik Erhardt & Elena Allen & Vince Calhoun & Marina Vannucci, 2018. "A Bayesian Approach for Estimating Dynamic Functional Network Connectivity in fMRI Data," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 113(521), pages 134-151, January.
  • Handle: RePEc:taf:jnlasa:v:113:y:2018:i:521:p:134-151
    DOI: 10.1080/01621459.2017.1379404
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    Citations

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    Cited by:

    1. Suprateek Kundu & Benjamin B. Risk, 2021. "Scalable Bayesian matrix normal graphical models for brain functional networks," Biometrics, The International Biometric Society, vol. 77(2), pages 439-450, June.
    2. Dimitrios Thomakos & Johannes Klepsch & Dimitris N. Politis, 2020. "Model Free Inference on Multivariate Time Series with Conditional Correlations," Stats, MDPI, vol. 3(4), pages 1-26, November.
    3. Daniel Spencer & Rajarshi Guhaniyogi & Raquel Prado, 2020. "Joint Bayesian Estimation of Voxel Activation and Inter-regional Connectivity in fMRI Experiments," Psychometrika, Springer;The Psychometric Society, vol. 85(4), pages 845-869, December.
    4. Changryong Baek & Benjamin Leinwand & Kristen A. Lindquist & Seok-Oh Jeong & Joseph Hopfinger & Katheleen M. Gates & Vladas Pipiras, 2023. "Detecting Changes in Correlation Networks with Application to Functional Connectivity of fMRI Data," Psychometrika, Springer;The Psychometric Society, vol. 88(2), pages 636-655, June.
    5. Yang Ni & Veerabhadran Baladandayuthapani & Marina Vannucci & Francesco C. Stingo, 2022. "Bayesian graphical models for modern biological applications," Statistical Methods & Applications, Springer;Società Italiana di Statistica, vol. 31(2), pages 197-225, June.

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