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A Semiparametric Single-Index Risk Score Across Populations

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  • Shujie Ma
  • Yanyuan Ma
  • Yanqing Wang
  • Eli S. Kravitz
  • Raymond J. Carroll

Abstract

We consider a problem motivated by issues in nutritional epidemiology, across diseases and populations. In this area, it is becoming increasingly common for diseases to be modeled by a single diet score, such as the Healthy Eating Index, the Mediterranean Diet Score, etc. For each disease and for each population, a partially linear single-index model is fit. The partially linear aspect of the problem is allowed to differ in each population and disease. However, and crucially, the single-index itself, having to do with the diet score, is common to all diseases and populations, and the nonparametrically estimated functions of the single-index are the same up to a scale parameter. Using B-splines with an increasing number of knots, we develop a method to solve the problem, and display its asymptotic theory. An application to the NIH-AARP Study of Diet and Health is described, where we show the advantages of using multiple diseases and populations simultaneously rather than one at a time in understanding the effect of increased Milk consumption. Simulations illustrate the properties of the methods. Supplementary materials for this article are available online.

Suggested Citation

  • Shujie Ma & Yanyuan Ma & Yanqing Wang & Eli S. Kravitz & Raymond J. Carroll, 2017. "A Semiparametric Single-Index Risk Score Across Populations," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 112(520), pages 1648-1662, October.
    • Handle: RePEc:taf:jnlasa:v:112:y:2017:i:520:p:1648-1662
    DOI: 10.1080/01621459.2016.1222944
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