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ADMET: ADipocyte METabolism mathematical model

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  • Alessio Micheloni
  • Gianni Orsi
  • Carmelo De Maria
  • Giovanni Vozzi

Abstract

White fat cells have an important physiological role in maintaining triglyceride and free fatty acid levels due to their fundamental storage property, as well as determining insulin resistance. ADipocyte METabolism is a mathematical model that mimics the main metabolic pathways of human white fat cell, connecting inputs (composition of culture medium) to outputs (glycerol and free fatty acid release). It is based on a set of nonlinear differential equations, implemented in Simulink® and controlled by cellular energetic state. The validation of this model is based on a comparison between the simulation results and a set of experimental data collected from the literature.

Suggested Citation

  • Alessio Micheloni & Gianni Orsi & Carmelo De Maria & Giovanni Vozzi, 2015. "ADMET: ADipocyte METabolism mathematical model," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 18(13), pages 1386-1391, October.
    • Handle: RePEc:taf:gcmbxx:v:18:y:2015:i:13:p:1386-1391
    DOI: 10.1080/10255842.2014.908855
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    References listed on IDEAS

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    1. Barbara Di Ventura & Caroline Lemerle & Konstantinos Michalodimitrakis & Luis Serrano, 2006. "From in vivo to in silico biology and back," Nature, Nature, vol. 443(7111), pages 527-533, October.
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