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From in vivo to in silico biology and back

Author

Listed:
  • Barbara Di Ventura

    (European Molecular Biology Laboratory)

  • Caroline Lemerle

    (European Molecular Biology Laboratory)

  • Konstantinos Michalodimitrakis

    (European Molecular Biology Laboratory)

  • Luis Serrano

    (European Molecular Biology Laboratory)

Abstract

The massive acquisition of data in molecular and cellular biology has led to the renaissance of an old topic: simulations of biological systems. Simulations, increasingly paired with experiments, are being successfully and routinely used by computational biologists to understand and predict the quantitative behaviour of complex systems, and to drive new experiments. Nevertheless, many experimentalists still consider simulations an esoteric discipline only for initiates. Suspicion towards simulations should dissipate as the limitations and advantages of their application are better appreciated, opening the door to their permanent adoption in everyday research.

Suggested Citation

  • Barbara Di Ventura & Caroline Lemerle & Konstantinos Michalodimitrakis & Luis Serrano, 2006. "From in vivo to in silico biology and back," Nature, Nature, vol. 443(7111), pages 527-533, October.
    • Handle: RePEc:nat:nature:v:443:y:2006:i:7111:d:10.1038_nature05127
    DOI: 10.1038/nature05127
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    Cited by:

    1. Nicola Lettieri & Antonio Altamura & Rosalba Giugno & Alfonso Guarino & Delfina Malandrino & Alfredo Pulvirenti & Francesco Vicidomini & Rocco Zaccagnino, 2018. "Ex Machina : Analytical platforms, Law and the Challenges of Computational Legal Science," Future Internet, MDPI, vol. 10(5), pages 1-25, April.
    2. Alessio Micheloni & Gianni Orsi & Carmelo De Maria & Giovanni Vozzi, 2015. "ADMET: ADipocyte METabolism mathematical model," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 18(13), pages 1386-1391, October.
    3. Jianhua Ruan, 2010. "A Top-Performing Algorithm for the DREAM3 Gene Expression Prediction Challenge," PLOS ONE, Public Library of Science, vol. 5(2), pages 1-8, February.

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