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Economic Burden of Treatment-Resistant Depression among Adults with Chronic Non-Cancer Pain Conditions and Major Depressive Disorder in the US

Author

Listed:
  • Drishti Shah

    (West Virginia University)

  • Lindsay Allen

    (West Virginia University)

  • Wanhong Zheng

    (West Virginia University)

  • Suresh S. Madhavan

    (West Virginia University
    University of North Texas Health Sciences Center)

  • Wenhui Wei

    (West Virginia University
    Regeneron Pharmaceuticals)

  • Traci J. LeMasters

    (West Virginia University)

  • Usha Sambamoorthi

    (West Virginia University
    University of North Texas Health Sciences Center)

Abstract

Objective Major depressive disorder (MDD) and chronic non-cancer pain conditions (CNPC) often co-occur and exacerbate one another. Treatment-resistant depression (TRD) in adults with CNPC can amplify the economic burden. This study examined the impact of TRD on direct total and MDD-related healthcare resource utilization (HRU) and costs among commercially insured patients with CNPC and MDD in the US. Methods The retrospective longitudinal cohort study employed a claims-based algorithm to identify adults with TRD from a US claims database (January 2007 to June 2017). Costs (2018 US$) and HRU were compared between patients with and without TRD over a 12-month period after TRD/non-TRD index date. Counterfactual recycled predictions from generalized linear models were used to examine associations between TRD and annual HRU and costs. Post-regression linear decomposition identified differences in patient-level factors between TRD and non-TRD groups that contributed to the excess economic burden of TRD. Results Of the 21,180 adults with CNPC and MDD, 10.1% were identified as having TRD. TRD patients had significantly higher HRU, translating into higher average total costs (US$21,015TRD vs US$14,712No TRD) and MDD-related costs (US$1201TRD vs US$471No TRD) compared with non-TRD patients (all p

Suggested Citation

  • Drishti Shah & Lindsay Allen & Wanhong Zheng & Suresh S. Madhavan & Wenhui Wei & Traci J. LeMasters & Usha Sambamoorthi, 2021. "Economic Burden of Treatment-Resistant Depression among Adults with Chronic Non-Cancer Pain Conditions and Major Depressive Disorder in the US," PharmacoEconomics, Springer, vol. 39(6), pages 639-651, June.
    • Handle: RePEc:spr:pharme:v:39:y:2021:i:6:d:10.1007_s40273-021-01029-2
    DOI: 10.1007/s40273-021-01029-2
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    References listed on IDEAS

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    1. Glick, Henry A. & Doshi, Jalpa A. & Sonnad, Seema S. & Polsky, Daniel, 2014. "Economic Evaluation in Clinical Trials," OUP Catalogue, Oxford University Press, edition 2, number 9780199685028.
    2. Oaxaca, Ronald, 1973. "Male-Female Wage Differentials in Urban Labor Markets," International Economic Review, Department of Economics, University of Pennsylvania and Osaka University Institute of Social and Economic Research Association, vol. 14(3), pages 693-709, October.
    3. Alan S. Blinder, 1973. "Wage Discrimination: Reduced Form and Structural Estimates," Journal of Human Resources, University of Wisconsin Press, vol. 8(4), pages 436-455.
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    1. David Proudman & Paul Greenberg & Dave Nellesen, 2021. "The Growing Burden of Major Depressive Disorders (MDD): Implications for Researchers and Policy Makers," PharmacoEconomics, Springer, vol. 39(6), pages 619-625, June.

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