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A general class of promotion time cure rate models with a new biological interpretation

Author

Listed:
  • Yolanda M. Gómez

    (Universidad de Atacama)

  • Diego I. Gallardo

    (Universidad de Atacama
    Universidad de Atacama)

  • Marcelo Bourguignon

    (Universidade Federal do Rio Grande do Norte)

  • Eduardo Bertolli

    (A.C.Camargo Cancer Center
    Beneficência Portuguesa)

  • Vinicius F. Calsavara

    (Cedars-Sinai Medical Center)

Abstract

Over the last decades, the challenges in survival models have been changing considerably and full probabilistic modeling is crucial in many medical applications. Motivated from a new biological interpretation of cancer metastasis, we introduce a general method for obtaining more flexible cure rate models. The proposal model extended the promotion time cure rate model. Furthermore, it includes several well-known models as special cases and defines many new special models. We derive several properties of the hazard function for the proposed model and establish mathematical relationships with the promotion time cure rate model. We consider a frequentist approach to perform inferences, and the maximum likelihood method is employed to estimate the model parameters. Simulation studies are conducted to evaluate its performance with a discussion of the obtained results. A real dataset from population-based study of incident cases of melanoma diagnosed in the state of São Paulo, Brazil, is discussed in detail.

Suggested Citation

  • Yolanda M. Gómez & Diego I. Gallardo & Marcelo Bourguignon & Eduardo Bertolli & Vinicius F. Calsavara, 2023. "A general class of promotion time cure rate models with a new biological interpretation," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 29(1), pages 66-86, January.
    • Handle: RePEc:spr:lifeda:v:29:y:2023:i:1:d:10.1007_s10985-022-09575-3
    DOI: 10.1007/s10985-022-09575-3
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    References listed on IDEAS

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    1. Guosheng Yin & Joseph G. Ibrahim, 2005. "A General Class of Bayesian Survival Models with Zero and Nonzero Cure Fractions," Biometrics, The International Biometric Society, vol. 61(2), pages 403-412, June.
    2. Hanin, Leonid & Huang, Li-Shan, 2014. "Identifiability of cure models revisited," Journal of Multivariate Analysis, Elsevier, vol. 130(C), pages 261-274.
    3. Stasinopoulos, D. Mikis & Rigby, Robert A., 2007. "Generalized Additive Models for Location Scale and Shape (GAMLSS) in R," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 23(i07).
    4. Li, Chin-Shang & Taylor, Jeremy M. G. & Sy, Judy P., 2001. "Identifiability of cure models," Statistics & Probability Letters, Elsevier, vol. 54(4), pages 389-395, October.
    5. Cooner, Freda & Banerjee, Sudipto & Carlin, Bradley P. & Sinha, Debajyoti, 2007. "Flexible Cure Rate Modeling Under Latent Activation Schemes," Journal of the American Statistical Association, American Statistical Association, vol. 102, pages 560-572, June.
    6. R. A. Rigby & D. M. Stasinopoulos, 2005. "Generalized additive models for location, scale and shape," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 54(3), pages 507-554, June.
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