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Nonparametric change point estimation for survival distributions with a partially constant hazard rate

Author

Listed:
  • Alessandra R. Brazzale

    (Università degli Studi di Padova)

  • Helmut Küchenhoff

    (Ludwig-Maximilians-Universität München)

  • Stefanie Krügel

    (Ludwig-Maximilians-Universität München)

  • Tobias S. Schiergens

    (Ludwig-Maximilians-Universität München)

  • Heiko Trentzsch

    (Ludwig-Maximilians-Universität München)

  • Wolfgang Hartl

    (Ludwig-Maximilians-Universität München)

Abstract

We present a new method for estimating a change point in the hazard function of a survival distribution assuming a constant hazard rate after the change point and a decreasing hazard rate before the change point. Our method is based on fitting a stump regression to p values for testing hazard rates in small time intervals. We present three real data examples describing survival patterns of severely ill patients, whose excess mortality rates are known to persist far beyond hospital discharge. For designing survival studies in these patients and for the definition of hospital performance metrics (e.g. mortality), it is essential to define adequate and objective end points. The reliable estimation of a change point will help researchers to identify such end points. By precisely knowing this change point, clinicians can distinguish between the acute phase with high hazard (time elapsed after admission and before the change point was reached), and the chronic phase (time elapsed after the change point) in which hazard is fairly constant. We show in an extensive simulation study that maximum likelihood estimation is not robust in this setting, and we evaluate our new estimation strategy including bootstrap confidence intervals and finite sample bias correction.

Suggested Citation

  • Alessandra R. Brazzale & Helmut Küchenhoff & Stefanie Krügel & Tobias S. Schiergens & Heiko Trentzsch & Wolfgang Hartl, 2019. "Nonparametric change point estimation for survival distributions with a partially constant hazard rate," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 25(2), pages 301-321, April.
  • Handle: RePEc:spr:lifeda:v:25:y:2019:i:2:d:10.1007_s10985-018-9431-x
    DOI: 10.1007/s10985-018-9431-x
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    References listed on IDEAS

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    1. Altun, Mustafa & Comert, Salih Vehbi, 2016. "A change-point based reliability prediction model using field return data," Reliability Engineering and System Safety, Elsevier, vol. 156(C), pages 175-184.
    2. Anestis Antoniadis & Irene Gijbels & Brenda Macgibbon, 2000. "Non‐parametric Estimation for the Location of a Change‐point in an Otherwise Smooth Hazard Function under Random Censoring," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 27(3), pages 501-519, September.
    3. Li, Yunxia & Qian, Lianfen & Zhang, Wei, 2013. "Estimation in a change-point hazard regression model with long-term survivors," Statistics & Probability Letters, Elsevier, vol. 83(7), pages 1683-1691.
    4. Chia-Han Yang & Tao Yuan & Way Kuo & Yue Kuo, 2012. "Non-parametric Bayesian modeling of hazard rate with a change point for nanoelectronic devices," IISE Transactions, Taylor & Francis Journals, vol. 44(7), pages 496-506.
    5. A. Mallik & B. Sen & M. Banerjee & G. Michailidis, 2011. "Threshold estimation based on a p-value framework in dose-response and regression settings," Biometrika, Biometrika Trust, vol. 98(4), pages 887-900.
    6. A. A. Noura & K. L. Q. Read, 1990. "Proportional Hazards Changepoint Models in Survival Analysis," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 39(2), pages 241-253, June.
    7. Jingle Wang & Ming Zheng & Wen Yu, 2014. "Wavelet Analysis of Change Points in Nonparametric Hazard Rate Models Under Random Censorship," Communications in Statistics - Theory and Methods, Taylor & Francis Journals, vol. 43(9), pages 1956-1978, May.
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